Selected Publications

  1. J.M. Monk, T.Y. Hou, H.F. Turk, B. Weeks, C. Wu, D.N. McMurrayand and R.S. Chapkin Dietary n-3 polyunsaturated fatty acids (PUFA) decrease obesity-associated Th17 cell-mediated inflammation during colitis. PLoS One 7(11)e49739, November, 2012. doi:10.1371/journal.pone.0049739. Download
  2. S.M. Donovan, M. Wang, M. Li, I. Friedberg, S.L. Schwartz R.S. Chapkin Host-microbe interactions in the neonatal intestine: Role of human milk oligosaccharides. Advances in Nutrition 3:450S-455S, 2012 Download
  3. H.F. Turk and R.S. Chapkin Membrane lipid raft organization is uniquely modified by n-3 polyunsaturated fatty acids. Prostaglandins Leukotrienes & Essential Fatty Acids. 2013 Jan;88(1):43-7. doi: 10.1016/j.plefa.2012.03.008. Epub 2012 Apr 18. PMID: 22515942 Download
  4. Y. Cho, N.D. Turner, L.A. Davidson, R.S. Chapkin, R.J. Carroll, J.R. Lupton. A chemoprotective fish oil/pectin diet enhances apoptosis via Bcl-2 promoter methylation in rat azoxymethane-induced carcinomas. Experimental Biology and Medicine 2012, 237:1387-1393. doi: 10.1258/ebm.2012.012244
  5. L.A. Davidson, J.S. Goldsby, E.S. Callaway, M.S. Shah, N. Barker and R.S. Chapkin (2012) Alteration of colonic stem cell gene signatures during the regenerative response to injury. Biochmicia et Biophysica Acta-Molecular Basis of Disease 1822:1600-1607, 2012. PMID: 22750333 Download
  6. H.F. Turk, R, Barhoumi and R.S. Chapkin. Alteration of EGFR spatiotemporal dynamics suppresses signal transduction. PLoS One 7(6):e39682, June, 2012. doi:10.1371/journal.pone.0039682 PMCID: PMC3384615 Download
  7. Y. Huo, X. Guo, H. Li, W. Zhang, H. Wang, Y.Y. Fan, H. Xu, C. Meng, V. Halim, G. Zhuang, R.L. Walzem, R.S. Chapkin, B. Zhou, D. G. Mashek, H. Dong, F. Lu, L. Wei, H.C. Towle and C.D. Wu. Targeted overexpression of inducible 6-phosphofructo-2-kinase in adipose tissue increases fat deposition but protects against diet-induced insulin resistance and inflammatory responses. Journal of Biological Chemistry 287:21492-21500, 2012. PMCID: PMC3375570 Download
  8. Y.Y. Fan, J. Monk, T. Hou, E. Callaway, L. Vincent, B. Weeks, P. Yang and R.S. Chapkin. Characterization of an arachidonic acid-deficient (FADS1 knock-out) mouse model. Journal of Lipid Research 53:1287-1295, 2012. PMID: 22534642Download
  9. S. Schwartz, I. Friedberg, I.V. Ivanov, L.A. Davidson, J.S. Goldsby, D.B. Dahl, D. Herman, M. Wang, S.M. Donovan and R.S. Chapkin. A Metagenomic study of diet-dependent interaction between gut microflora and host in infants reveals differences in developmental and immune responses. Genome Biology 13:R32 doi:10.1186/gb-2012-13-4-r32. PMID: 22546241 Download
  10. T.Y. Hou, J.M. Monk, Y.Y. Fan, R. Barhoumi, Y. Chen, G.M. Rivera, D.N. McMurray and R.S. Chapkin. n-3 polyunsaturated fatty acids suppress phosphatidylinositol-(4,5)-bisphosphate dependent actin remodeling during CD4+ T cell activation. Biochemical Journal 443:27-37, 2012. PMID:22250985 Download
  11. M. Saldua, C. Olsovsky, E.S. Callaway, R.S. Chapkin, K.C. Maitland. Imaging inflammation in mouse colon using a rapid stage scanning confocal fluorescence microscope. Journal of Biomedical Optics, January 17, 016006 (2012), DOI:10.1117/1.JBO.17.1.016006 Download
  12. J.M. Monk, Q. Jia, E. Callaway, B. Weeks, R.C. Alaniz, D.N. McMurray and R.S. Chapkin. n-3 PUFA decrease Th17 cell accumulation in chronic dextran sodium sulfate (DSS)-induced colitis. Journal of Nutrition 142:117-124, 2012. PMID:22131549 Download
  13. J.M. Monk, W. Kim, E. Callaway, W. He, B. Weeks, R.C. Alaniz, D.N. McMurray and R.S. Chapkin. Immunomodulatory action of dietary fish oil and targeted deletion of intestinal epithelial cell PPAR? in inflammation-induced colon carcinogenesis. American Journal of Physiology – GI Physiology 302:G153-G167, 2012. PMCID: PMC3345959 Download
  14. Y. Cho, H. Kim, N.D. Turner, J.C. Mann, J. Wei, S.S. Taddeo, L.A. Davidson, N. Wang, M. Vannucci, R.J. Carroll, R.S. Chapkin and J.R. Lupton. A chemoprotective fish oil/pectin-containing diet temporally alters gene expression profiles in exfoliated rat colonocytes throughout oncogenesis. Journal of Nutrition 141:1029-1035, 2011. PMCID: PMC3095137
  15. M. Shah, S.L. Schwartz, C. Zhao, L.A. Davidson, B. Zhou, J.R. Lupton, I. Ivanov and R.S. Chapkin. Integrated microRNA and mRNA expression profiling in a rat colon carcinogenesis model: Effect of a chemoprotective diet. Physiological Genomics 43:640-653, 2011. PMCID: PMC3110886Download
  16. S. Kolar, R. Barhoumi, C.K. Jones, J. Wesley, J.R. Lupton, Y.Y. Fan and R.S. Chapkin. Interactive effects of fatty acid and butyrate-induced mitochondrial Ca2+ loading and apoptosis in colonocytes. Cancer 117:5294-5303, 2011. PMCID: PMC3156959Download
  17. Y.Y. Fan, Q. Ran, S. Toyokuni, Y. Okazaki, E.S. Callaway, J.R. Lupton, and R.S. Chapkin. Dietary fish oil promotes colonic apoptosis and mitochondrial proton leak in oxidatively stressed mice. Cancer Prevention Research, 4:1267-1274, 2011. PMCID: PMC3137683 Download
  18. P. Kachroo, I. Ivanov, L.A. Davidson, B.P. Chowdhary, J.R. Lupton and R.S. Chapkin. Classification of diet-modulated gene signatures at the colon cancer initiation and progression stages. Digestive Diseases and Sciences. 56:2595-2604, 2011. PMCID: PMC3139012Download
  19. Q. Jia, I. Ivanov, Z.Z. Zlatev, R.C. Alaniz, B.R. Weeks, E. Callaway, J.S. Goldsby, L.A. Davidson, Y.Y. Fan, L. Zhou, J.R. Lupton, D. N. McMurray and R.S. Chapkin. Fish oil and curcumin combination modulate colonic cytokinetics and gene expression in DSS-treated mice. British Journal of Nutrition 106:519-529, 2011. PMID:21401974Download
  20. H.F. Turk, S.S. Kolar, Y.Y. Fan, C.A. Cozby, J.R. Lupton and R.S. Chapkin. Linoleic acid and butyrate synergize to increase bcl-2 in colonocytes. International Journal of Cancer 128:63-71, 2011. Download
  21. T.Y. Hou, J.M Monk, Y.Y. Fan, R. Barhoumi, Y.Q. Chen, G.M. Rivera, D.N. McMurray and R.S. Chapkin (2012) n-3 polyunsaturated fatty acids suppress phosphatidylinositol 4,5-bisphosphate-dependent actin remodelling during CD4+ T-cell activation. Biochem J 443: 27-37 Download
  22. J.M. Monk, D.N. McMurray and R.S. Chapkin. Clinical effects of n-3 PUFA supplementation in health and inflammatory diseases. In: Omega 3 oils: Applications in Functional Foods. Eds., E. Hernandez and M. Hoskawa. American Oil Chemists’ Society, 2011.Download
  23. Y. Cho, H. Kim, N.D. Turner, J.C. Mann, J. Wei, S.S. Taddeo, L.A. Davidson, N. Wang, M. Vannucci, R.J. Carroll, R.S. Chapkin and J.R. Lupton. Temporal analysis of a chemoprotective diet: Fish oil/pectin feeding alters gene expression profiles in exfoliated colonocytes throughout colon oncogenesis. J Nutr 141: 1029-35.Download
  24. R.S. Chapkin and S.M. Donovan. Diapers’ contents could revolutionize the way we monitor infant intestinal development and disease susceptibility. Pediatrics for Parents; The Newsletter for Caring Adults. (In Press, 2011).Download
  25. Zhang, Z., Lanza, E., Kris-Etherton, P.M., Colburn, N.H., Bagshaw, D., Rovine, M.J., Ulbrecht, J.S., Bobe, G., Chapkin, R.S. and Hartman, T.J. A high legume low glycemic index diet improves serum lipid profiles in men. Lipids 45:765-775, 2010.Download
  26. W. Kim, D.N. McMurray and R.S. Chapkin. n-3 polyunsaturated fatty acids – physiological relevance and dose. Prostaglandins Leukotrienes & Essential Fatty Acids 82:155-158, 2010.Download
  27. W. Kim, N.A. Khan, D.N. McMurray, I.A. Prior, N. Wang and R.S. Chapkin. Regulatory activity of polyunsaturated fatty acids in T-cell signaling. Progress in Lipid Research 49:250-261, 2010.Download
  28. T. Leonardi, J. Vanamala, S.S. Taddeo, L.A. Davidson, M.E. Murphy, B.S. Patil, N. Wang, R.J. Carroll, R.S. Chapkin, J.R. Lupton, N.D. Turner. Apigenin and naringenin suppress colon carcinogenesis through the aberrant crypt stage in azoxymethane-treated rats. Experimental Biology and Medicine.Download
  29. D.L.Bonilla, L.H.Ly, Y.Y.Fan, R.S.Chapkin, and D.N.Murray. Incorporation of omega-3 fatty acids impairs macrophage responses to Mycobacterium tuberculosis. PLoS ONE.Download
  30. R.S. Chapkin,Chen Zhao1,Michael L. Bittner and Edward R. Dougherty.Characterization of the Effectiveness of Reporting Lists of Small Feature Sets Relative to the Accuracy of the Prior Biological Knowledge. Cancer Informatics 9:4960, 2010Download
  31. R.S. Chapkin,Rajeshwari Yog, Rola Barhoumi, David N. McMurray. n-3 Polyunsaturated Fatty Acids Suppress Mitochondrial Translocation to Q:1 the Immunologic Synapse and Modulate Calcium Sig Q:2 naling in T Cells. Journal of Immunology 184:5864-5873, 2010Download
  32. H.F. Turk, S.S. Kolar, Y.Y. Fan, C.A. Cozby, J.R. Lupton and R.S. Chapkin. Linoleic acid and butyrate synergize to increase bcl-2 in colonocytes. International Journal of Cancer (In press).Download
  33. R.S. Chapkin,Chen Zhao, Ivan Ivanov, Laurie A. Davidson, Jennifer S. Goldsby, Joanne R. Lupton1, Rose Ann Mathai, Marcia H. Monaco, Deshanie Rai, W. Michael Russell Sharon M. Donovan, and Edward R. Dougherty.Non-invasive stool-based detection of infant gastrointestinal development using gene expression profiles from exfoliated epithelial cells. American Journal of Physiology 298:G582-G589, 2010Download
  34. R.S. Chapkin,Yuqing Huo, Xin Guo, Honggui Li, Huan Wang, Weiyu Zhang, Ying Wang, Huaijun Zhou, Zhanguo Gao, Sucheta Telang, Jason Chesney, Y. Eugene Chen, Jianping Ye, and Chaodong Wu.Disruption of Inducible 6-Phosphofructo-2-kinase Ameliorates Diet-induced Adiposity but Exacerbates Systemic Insulin Resistance and Adipose Tissue Inflammatory Response. Journal of Biological Chemistry 285:3713-3721, 2010Download
  35. C.A. Warren, K.J. Paulhill, L.A. Davidson, J.R. Lupton, S.S. Taddeo, M.Y. Hong, R.J. Carroll, R.S. Chapkin and N.D. Turner. Quercetin may suppress rat aberrant crypt foci by suppressing inflammatory mediators that influence proliferation and apoptosis. Journal of Nutrition 139:101-105, 2009. PMC Journal – In Process.Download
  36. N.D. Turner, Paulhill, K.J., Warren, C.A., Carroll, R.J., Wang, N., Davidson, L.A., Chapkin, R.S.and Lupton, J.R. Quercetin suppresses early colon carcinogenesis partly through inhibition of inflammatory mediators. Acta Horticulturae 841:237-241, 2009.
  37. R.S. Chapkin, B.A. Kamen, E.S. Callaway, L.A. Davidson, N.I. George, N. Wang, J.R. Lupton and R.H. Finnell. Use of a novel genetic mouse model to investigate the role of folate in colitis-associated colon cancer. Journal of Nutritional Biochemistry 79:649-655, 2009.Download
  38. R.S. Chapkin,Laurie A.Davidson, Naisyin Wang, Manasvi S.Shah1, Joanne R.Lupton, Ivan Ivanov. n-3 Polyunsaturated fatty acids modulate carcinogen-directed non-coding microRNA signatures in rat colon. Carcinogenesis 30:2077-2084, 2009.Download
  39. V.E. Kagan, A. Bayir, H. Bayir, D. Stoyanovsky, G.G. Borienko, Y.Y. Tyurina, P. Wipf, J. Atkinson, J.S. Greenberger, R.S. Chapkin and N.A. Belikova. Mitochondria-targeted disruptors and inhibitors of cyt c/CL peroxidase complexes: A new strategy in anti-apoptotic drug discovery. Molecular Nutrition 53(1):104-14, 2009. PMC2659540
  40. C. Zhao, I. Ivanov, E.R. Dougherty, T.J. Hartman, E. Lanza, N.H. Colburn, J.R. Lupton, L.A. Davidson and R.S. Chapkin. Non-invasive detection of candidate molecular biomarkers in subjects with a history of insulin resistance and colorectal adenomas. Cancer Prevention Research 2:590-597, 2009.
  41. W. Kim, Y.Y. Fan, R. Smith, B. Patil, G.K Jayaprakasha, D.N. McMurray, and R.S. Chapkin. Dietary curcumin and limonin suppress CD4+ T-cell proliferation and interleukin-2 production in mice. Journal of Nutrition 139:1042-1048, 2009. Download
  42. W. Kim, D.N. McMurray and R.S. Chapkin. Chemotherapeutic properties of n-3 polyunsaturated fatty acids – old concepts and new insights. Immun. Endoc. Metab. Agents in Med. Chem. 9:38-44, 2009. PMC Journal – In Process.
  43. Y.Y. Fan, L.A. Davidson, L. Zhou, E. Callaway, Y. Tian, B.R. Weeks, J.R. Lupton, S. Toyokuni and R.S. Chapkin. Proapoptotic effects of (n-3) fatty acids are enhanced in colonocytes of manganese-dependent superoxide dismutase knockout mice. Journal of Nutrition 139:1328-1332, 2009. Download
  44. L.A. Davidson, N. Wang, I. Ivanov, J. Goldsby, J.R. Lupton and R.S. Chapkin. Identification of actively translated mRNA transcripts in a rat model of early stage colon carcinogenesis. Cancer Prevention Research 2:984-994, 2009.Download
  45. D.L. Bonilla, Y.Y. Fan, R.S. Chapkin and D.N. McMurray. Transgenic mice enriched in omega-3 fatty acids are more susceptible to Mycobacterium tuberculosis infection. Journal of Infectious Disease 201:299-408, 2010.Download
  46. R.S. Chapkin, B.A. Kamen, E.S. Callaway, L.A. Davidson, N.I. George, N. Wang, J.R. Lupton and R.H. Finnell. Use of a novel genetic mouse model to investigate the role of folate in colitis-associated colon cancer. Journal of Nutritional Biochemistry 79:649-655, 2009.
  47. V.E. Kagan, A. Bayir, H. Bayir, D. Stoyanovsky, G.G. Borienko, Y.Y. Tyurina, P. Wipf, J. Atkinson, J.S. Greenberger, R.S. Chapkin and N.A. Belikova. Mitochondria-targeted disruptors and inhibitors of cyt c/CL peroxidase complexes: A new strategy in anti-apoptotic drug discovery. Molecular Nutrition Food Research 53:104-114, 2009.
  48. W. Kim, D.N. McMurray and R.S. Chapkin. Chemotherapeutic properties of n-3 polyunsaturated fatty acids – Old concepts and new insights. Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry 9:38-44, 2009.Download
  49. R.S. Chapkin, W. Kim, J.R. Lupton and D.N. McMurray. Dietary docosahexaenoic and eicosapentaenoic acid: Emerging mediators of inflammation. Prostaglandins Leukotrienes & Essential Fatty Acids 81:187-191, 2009.Download
  50. W. Kim, R.S. Chapkin, R. Barhoumi and D.W.L. Ma. A novel role for nutrition in the alteration of functional microdomains on the cell surface. In: Methods in Molecular Biology – Protocols series (Lipidomics). Armstrong, D. ed., Humana Press Inc, Vol. 579, pp. 261-279, 2009.Download
  51. R.S. Chapkin, B.A. Kamen, E.S. Callaway, L.A. Davidson, N.I. George, N. Wang, J.R. Lupton and R.H. Finnell. Use of a novel genetic mouse model to investigate the role of folate in colitis-associated colon cancer. Journal of Nutritional Biochemistry (In press). Download
  52. Y.Y. Fan, W. Kim, E. Callaway, R. Smith, Q. Jia, L. Zhou, D.N. McMurray and R.S. Chapkin. fat-1 transgene expression prevents cell culture-induced loss of membrane n-3 fatty acids in activated CD4+ T-cells. Prostaglandins Leukotrienes & Essential Fatty Acids (In press).
  53. C.A. Warren, K.J. Paulhill, L.A. Davidson, J.R. Lupton, S.S. Taddeo, M.Y. Hong, R.J. Carroll, R.S. Chapkin and N.D. Turner. Quercetin may suppress rat aberrant crypt foci by suppressing inflammatory mediators that influence proliferation and apoptosis. Journal of Nutrition 139:101-105, 2009. Download
  54. W. Kim, Y.Y. Fan, R. Smith, B. Patil, G.K. Jayaprahasha, D.N. McMurray and R.S. Chapkin. Dietary curcumin and limonin suppress CD4+ T-cell proliferation and interleukin-2 production. Journal of Nutrition 139:1042-1048, 2009. Download
  55. C. Zhao, I. Ivanov, E.R. Dougherty, T.J. Hartman, E. Lanza, N.H. Colburn, J.R. Lupton, L.A. Davidson and R.S. Chapkin. Non-invasive detection of candidate molecular biomarkers in subjects with a history of insulin resistance and colorectal adenomas. Cancer Prevention Research 2:590-597, 2009. Download
  56. V.E. Kagan, A. Bayir, H. Bayir, D. Stoyanovsky, G.G. Borienko, Y.Y. Tyurina, P. Wipf, J. Atkinson, J.S. Greenberger, R.S. Chapkin and N.A. Belikova. Mitochondria-targeted disruptors and inhibitors of cyt c/CL peroxidase complexes: A new strategy in anti-apoptotic drug discovery. Molecular Nutrition Food Research 53:104-114, 2009. Download
  57. W. Kim, D.N. McMurray and R.S. Chapkin. Chemotherapeutic properties of n-3 polyunsaturated fatty acids – Old concepts and new insights. Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry 9:38-44, 2009. Download
  58. V.E. Kagan, A. Bayir, H. Bayir, D. Stoyanovsky, G.G. Borienko, Y.Y. Tyurina, P. Wipf, J. Atkinson, J.S. Greenberger, R.S. Chapkin and N.A. Belikova. Mitochondria-targeted disruptors and inhibitors of cyt c/CL peroxidase complexes: A new strategy in anti-apoptotic drug discovery. Molecular Nutrition 53(1): 104-114, 2009. Download
  59. W. Kim, Y.Y. Fan, R. Barhoumi, R. Smith, D.N. McMurray and R.S. Chapkin. n-3 polyunsaturated fatty acids suppress the localization and activation of signaling proteins at the immunological synapse in murine CD4+ cells by affecting membrane raft formation. Journal of Immunology 181: 6236-6243, 2008. Download
  60. C. McFarland, Y.Y. Fan, R.S. Chapkin, B. Weeks and D.N. McMurray. Dietary polyunsaturated fatty acids modulate resistance to M. tuberculosis in guinea pigs. Journal of Nutrition 138: 2123-2128, 2008. Download
  61. Q. Jia, J.R. Lupton, R. Smith, B. Weeks, E. Callaway, L.A. Davidson, W. Kim, Y.Y. Fan, P. Yang, R. Newman, J. Kang, D.N. McMurray and R.S. Chapkin. Reduced colitis-associated colon cancer in Fat-1 (n-3 fatty acid desaturase) transgenic mice. Cancer Research 68:3985-3991, 2008. Download
  62. K.C. Crim, L. Sanders, M.Y. Hong, S. Taddeo, N.D. Turner, R.S. Chapkin and J.R. Lupton. Upregulation of p21waf1/cip1 expression in vivo by butyrate administration can be chemoprotective or chemopromotive depending on the lipid component of the diet. Carcinogenesis 29:1415-1420, 2008. Download
  63. J. Vanamala, A. Glagolenko, P. Yang, R.J. Carroll, M.E. Murphy, R.A. Newman, R.S. Chapkin and J.R. Lupton. Dietary fish oil and pectin enhance colonocyte apoptosis in irradiated rats in part by suppressing protumorigenic signaling. Carcinogenesis 29:790-796, 2008. Download
  64. R.S. Chapkin, N. Wang, Y.Y. Fan, J.R. Lupton and I.A. Prior. Docosahexaenoic acid alters the size and distribution of cell surface microdomains. Biochimica et Biophysica Acta – Biomembranes 1778:466-471, 2008.
  65. R.S. Chapkin, J. Seo, D.N. McMurray and J.R. Lupton. Mechanisms by which docosahexaeonic acid and related fatty acids reduce colon cancer risk and inflammatory disorders of the intestine. Chemistry and Physics of Lipids 153:14-23, 2008.
  66. R.S. Chapkin, D.N. McMurray, L.A. Davidson, B.S. Patil, Y.Y. Fan and J.R. Lupton. Bioactive dietary long chain fatty acids: Emerging mechanisms of action. British Journal of Nutrition (May 20, 1-6), 2008.
  67. T.V. Apanasovich, D. Ruppert, J.R. Lupton, N. Popovic, N.D. Turner, R.S. Chapkin and R.J. Carroll. Aberrant crypt foci and semiparametric modeling of correlated binary data. Biometrics 64:490-500, 2008.
  68. S.S. Kolar, R. Barhoumi, E.S. Callaway, Y.Y. Fan, N. Wang, J.R. Lupton and R.S. Chapkin. Synergy between docosahexaenoic acid and butyrate elicits p53-independent apoptosis via mitochondrial Ca2+ accumulation in human colon cancer cells and primary cultures of rat colonic crypts. American Journal of Physiology: GI and Liver Physiology 293:G935-G943, 2007.
  69. R.S. Chapkin. R.S. Chapkin. Reappraisal of the essential fatty acids. In: Fatty Acids in Food and Their Health Implications, 3rd Edition. (Chow, C.K. ed.), CRC Press, pp. 675-691, 2008.
  70. S.S. Kolar, R. Barhoumi, J.R. Lupton and R.S. Chapkin. Docosahexaenoic acid and butyrate synergistically induce colonocyte apoptosis by enhancing mitochondrial Ca2+ accumulation. Cancer Research 67:561-5568, 2007.
  71. R.S. Chapkin, D.N. McMurray and J.R. Lupton. Colon cancer, fatty acids and anti-inflammatory compounds. Current Opinion in Gastroenterology 23:48-54, 2007.
  72. R.S. Chapkin, L.A. Davidson, L. Ly, B.R. Weeks, J.R. Lupton, and D.N. McMurray. Immunomodulatory effects of omega-3 fatty acids: to inflammation and colon cancer. Journal of Nutrition 137:200S-204S, 2007.
  73. P. Zhang, W. Kim, R., L. Zhou, N. Wang, L.H. Ly, D.N. McMurray and R.S. Chapkin. Dietary fish oil inhibits antigen-specific Th1 cell development by suppression of clonal expansion. Journal of Nutrition 136:2391-2398, 2006.
  74. J. Seo, R. Barhoumi, A.E. Johnson, J.R. Lupton and R.S. Chapkin. Docosahexaenoic acid selectively inhibits plasma membrane targeting of lipidated proteins. FASEB Journal express article 10.1096/fj.05-4683fje, 20:770-772, 2006.
  75. J. Vanamala, T. Leonardi, B.S. Patil, S.S. Taddeo, M.E. Murphy, L.M. Pike, R.S. Chapkin, J.R. Lupton and N.D. Turner. Suppression of colon carcinogenesis by bioactive compounds in grapefruit. Carcinogenesis 27:1257-1265, 2006.
  76. L.H. Ly, R. Smith, K.C. Switzer, R.S. Chapkin, and D.N. McMurray. Dietary eicosapentaenoic acid modulates CTLA-4 expression in murine CD4+ T-cells. Prostaglandins, Leukotrienes and Essential Fatty Acids 74:29-37, 2006.
  77. W. Stillwell, S.R. Shaikh, D. LoCascio, R.A. Siddiqui, J. Seo, R.S. Chapkin and S.R. Wassall. Docosahexaenoic acid. An important membrane-altering omega-3 fatty acid. In: Omega-3 fatty acids: New research, Nova Science Publishers, Inc, Hauppauge, NY, Chapter 8, pp. 249-271, 2006.
  78. L.H. Ly, R. Smith, R.S. Chapkin and D.N. McMurray. Dietary n-3 polyunsaturated fatty acids suppress splenic CD4+ T-cell function in IL-10 (-/-) mice. Clinical & Experimental Immunology 139: 202-209, 2005.
  79. Y. Ng, R. Barhoumi, R.B. Tjalkens, Y.Y. Fan, S. Kolar, N. Wang, J.R. Lupton and R.S. Chapkin. The role of docosahexaenoic acid mediating mitochondrial membrane lipid oxidation and apoptosis in colonocytes. Carcinogenesis 26:1914-1921, 2005.
  80. P. Zhang, R. Smith, R.S. Chapkin and D.N. McMurray. Dietary n-3 Polyunsaturated fatty acids modulate the Th1/Th2 balance towards the Th2 pole by suppression of Th1 development. Journal of Nutrition 135:1745-1751, 2005.
  81. G.D. Zhou, N. Popovic, J.R. Lupton, N.D. Turner, R.S. Chapkin and K.C. Donnelly. Tissue-specific attenuation of endogenous DNA I-compounds in rats by carcinogen azoxymethane: possible role of fish oil in colon cancer prevention. Cancer Epidemiology Biomarkers & Prevention 14:1230-1235, 2005.
  82. M.Y. Hong, L.K. Bancroft, N.D. Turner, L.A. Davidson, M.E. Murphy, R.J. Carroll, R.S. Chapkin, and J.R. Lupton. Fish oil decreases oxidative DNA damage by enhancing apoptosis in rat colon. Nutrition & Cancer 52:166-175, 2005.
  83. M.Y. Hong, N.D. Turner, R.J. Carroll, R.S. Chapkin and J.R. Lupton. Differential response to DNA damage may explain different cancer susceptibility between small and large intestine. Experimental Biology & Medicine 230:464-471, 2005.
  84. L.D. Liu, N. Wang, J.R. Lupton, N.D. Turner, R.S. Chapkin and L.D. Davidson. A two-stage normalization method for partially degraded mRNA microarray data. Bioinformatics 21:4000-4006, 2005.
  85. M. Leyk, D.V. Nguyen, S.N. Atoor, E.R. Dougherty, N.D. Turner, L.K. Bancroft, R.S. Chapkin, J.R. Lupton and R.J. Carroll. Comparing automatic and manual image processing in FLARE assay analysis for colon carcinogenesis. Statistical Applications in Genetics and Molecular Biology 4:1-18, Article 5, 2005 http://www.bepress.com/sagmb/vol4/iss1/art5.
  86. D.W.L. Ma, R.H. Finnell, L.A. Davidson, E.S. Callaway, O. Spiegelstein, J.A. Piedrahita, J.M. Salbaum, C. Kappen, B. Weeks, J. James, D. Bozinov, J.R. Lupton and R.S. Chapkin. Folate transport gene inactivation in mice increases sensitivity to colon carcinogenesis. Cancer Research 65:887-897, 2005.
  87. D.W.L. Ma, J. Seo, K.C. Switzer, Y.Y. Fan, D.N. McMurray, J.R. Lupton and R.S. Chapkin. n-3 PUFA and membrane microdomains: a new frontier in bioactive lipid research. Journal of Nutritional Biochemistry 15:700-706, 2004.Download
  88. K.C. Switzer, D.N. McMurray and R.S. Chapkin. Effects of dietary n-3 polyunsaturated fatty acids on T cell membrane composition and function: a unifying hypothesis. Lipids, 2005.
  89. Y.Y. Fan, L.H. Ly, R. Barhoumi, D.N. McMurray and R.S. Chapkin. Dietary docosahexaenoic acid suppresses T-cell protein kinase C-theta lipid raft recruitment and interleukin-2 production. Journal of Immunology 173:6151-6160, 2004.Download
  90. L.M. Sanders, C.E. Henderson, M.Y. Hong, R. Barhouim, R.C. Burghardt, N. Wang, C.M. Spinka, R.J. Carroll, N.D. Turner, R.S. Chapkin and J.R. Lupton. An Increase in Reactive Oxygen Species by Dietary Fish Oil Coupled with the Attenuation of Antioxidant Defenses by Dietary Pectin Enhances Rat Colonocyte Apoptosis. Journal of Nutrition 134:3233-3238, 2004.Download
  91. L.A. Davidson, D.V. Nyuyen, R.M. Hokanson, E.S. Callaway, R.B. Isett, N.D. Turner, E.R. Dougherty, J.R. Lupton, R.J. Carroll and R.S. Chapkin. Chemopreventive n-3 polyunsaturated fatty acids reprogram genetic signatures during colon cancer initiation and progression in the rat. Cancer Research 64:6797-6804, 2004.Download
  92. R.C. Zangar, Y.Y. Fan and R.S. Chapkin. Interactions of phospholipase D and cytochrome P450 protein stability. Biochemical Pharmacology, 68:503-512, 2004. Download
  93. D.W.L. Ma, J. Seo, L.A. Davidson, E.S. Callaway, Y.Y. Fan, J.R. Lupton and R.S. Chapkin. n-3 PUFA alter caveolae lipid composition and resident protein localization in mouse colon. Faseb Journal, April 2004, 10.1096/fj.03-0604fje Download, 18: 1040-1042, June 2004 Download
  94. L.M. Sanders, C.E. Henderson, M.Y. Hong, R. Barhoumi, R.C. Burghardt, R.J. Carroll, N.D. Turner, R.S. Chapkin and J.R. Lupton. Pro-oxidant environment of the colon compared to the small intestine may contribute to greater cancer susceptibility. Cancer Letters 208:155-161, 2004.Download
  95. K.C. Switzer, Y-Y. Fan, N. Wang, D.M. McMurray and R.S. Chapkin. Dietary n-3 polyunsaturated fatty acids promote activation-induced cell death in the Th1-polarized murine CD4+ T-cells. Journal of Lipid Research, 45:1482-1492, 2004.
  96. T.V. Apanasovich, S. Sheather, J.R. Lupton, N. Popovic, N.D. Turner, R.S. Chapkin and R.J. Carroll. Testing for spatial correlation in binary data with application to aberrant crypt foci in colon carcinogenesis. Biometrics 59:752-761, 2003.
  97. M.H. Hong, R.S. Chapkin, L.A. Davidson, N.D. Turner, J.S. Morris, R.J. Carroll and J.R. Lupton. Fish oil enhances targeted apoptosis during colon tumor initiation in part by down regulating BCL-2. Nutrition & Cancer 46:44-51, 2003. Download
  98. Y.Y. Fan, T.E. Spencer, N. Wang, M.P. Moyer and R.S. Chapkin. Chemopreventive n-3 fatty acids activate RXRa in colonocytes. Carcinogenesis 24:1-8, 2003. Download
  99. L.K. Bancroft, J.R. Lupton, L.A. Davidson, S.S. Taddeo, M.E. Murphy, R.J. Carroll and R.S. Chapkin. Dietary fish oil reduces oxidative DNA damage in rat colonocytes. Free Radical Biology & Medicine 35:149-159, 2003. Download
  100. Y.Y. Fan, D.N. McMurray, L.H. Ly and R.S. Chapkin. Dietary n-3 polyunsaturated fatty acids remodel mouse T cell lipid rafts. Journal of Nutrition 133: 1913-1920, 2003. Download
  101. K.C. Switzer, D.N. McMurray, J.S. Morris and R.S. Chapkin. Dietary n-3 polyunsaturated fatty acids selectively promote activation-induced cell death in T-lymphocytes. Journal of Nutrition 133:496-503, 2003. Download
  102. L.A. Davidson, J.R. Lupton, E. Miskovsky, A.P. Fields and R.S. Chapkin. Quantitation of human intestinal gene expression profiles using exfoliated colonocytes: A pilot study. Biomarkers. Biomarkers 8(1):51-61, 2003. Download
  103. J.S. Morris, N.Wang, J.R. Lupton, R.S. Chapkin, N.D. Turner, M.Y. Hong and R.J. Carroll. A Baysian analysis of colonic crypt structure and signaling incorporating missing crypts. Biostatistics 3:529-546, 2002.
  104. M.Y. Hong, R.S. Chapkin, R. Barhoumi, R.C. Burghardt, N.D. Turner, C.E. Henderson, L.M. Sanders, Y.Y. Fan, L.A. Davidson, M. Murphy, R.J. Carroll and J.R. Lupton. Fish oil feeding increases the unsaturation index in mitochondrial phospholipids, enhancing reactive oxygen species generation and initiating apoptosis in rat colonocytes. Carcinogenesis 23:1919-1925, 2002.
  105. R.S. Chapkin, J.L. Arrington, T.V. Apanasovich, R.J. Carroll and D .N. McMurray. Dietary n-3 PUFA affect TcR-mediated activation of purified murine T cells and accessory cell function in co-cultures. Clinical and Experimental Immunology 130:12-18, 2002.
  106. N.D. Turner, J. Zhang, L.A. Davidson, J.R. Lupton and R.S. Chapkin. Oncogenic ras alters sensitivity of mouse colonocytes to butyrate and fatty acid mediated growth arrest and apoptosis. Cancer Letters 186:29-35, 2002.
  107. N.R. Murray, C. Weems, L. Chen, J. Leon, W. Yu, L.A. Davidson, L. Jamieson, R.S. Chapkin, A. Thompson, A.P. Fields. Protein kinase CbII and TGFbRII in W-3 fatty acid-mediated inhibition of colon carcinogenesis. Journal of Cell Biology 157:915-920, 2002.
  108. R.S. Chapkin, M.Y. Hong, Y.Y. Fan, L.A. Davidson, L.M. Sanders, C.E. Henderson, N.D. Turner, R. Barhoumi, R.C. Burghardt and J.R. Lupton. Dietary n-3 PUFA alter colonocyte mitochondrial membrane composition and function. Lipids 37:193-199, 2002.Download
  109. M.Y. Hong, R.S. Chapkin, J.S. Morris, N. Wang, R.J. Carroll, N.D. Turner, W.C. Chang, L.A. Davidson and J.R. Lupton. Anatomical site-specific response to DNA damage is related to later tumor development in the rat AOM colon carcinogenesis model. Carcinogenesis 22:1831-1835, 2001.
  110. J.S. Morris, N. Wang, J.R. Lupton, R.S. Chapkin, N.D. Turner, M.Y. Hong and R.J. Carroll. Parametric and non parametric methods for understanding the relationship between carcinogen-induced DNA adduct levels in distal and proximal regions of the colon. Journal of the American Statistical Association 96:816-826, 2001.
  111. J.L. Arrington, R.S. Chapkin, K.C. Switzer, J.S. Morris and D.N. McMurray. Dietary n-3 polyunsaturated fatty acids modulate purified murine T-cell subset activation. Clinical and Experimental Immunology 125:499-507, 2001.
  112. D.Y. Fan, K.S. Ramos and R.S. Chapkin. Dietary primrose oil containing gammalinolenic acid suppresses smooth muscle proliferation and reduces atherosclerosis in Apo E knock-out mice. Journal of Nutrition 131:1675-1681, 2001.
  113. J.L.Arrington, K.C. Switzer, Y.Y. Fan, D.N. McMurray and R.S. Chapkin. Docosahexaenoic acid suppresses function of the CD28 costimulatory membrane receptor function in primary murine and Jurkat T cells. Journal of Nutrition 131:1147-1153, 2001.
  114. E.D. Collett, L.A. Davidson, J.R. Lupton and R.S. Chapkin. n-6 and n-3 polyunsaturated fatty acids differentially modulate oncogenic ras activation in colonocytes. American Journal of Physiology: Cell Physiology 280:C1066-C1075, 2001.
  115. M.Y. Hong, J.R. Lupton, J.S. Morris, N.Wang, R.J. Carroll, L.A. Davidson, R.H. Elder and R.S. Chapkin. Dietary fish oil reduces DNA adduct levels in rat colon in part by increasing apoptosis during tumor initiation. Cancer Epidemiology Biomarkers and Prevention 9:819-826, 2000.
  116. D.N. McMurray, C.A. Jolly and R.S. Chapkin. Effect of dietary n-3 fatty acids on T cell activation and T cell receptor mediated signalling in a murine model. Journal of Infectious Disease 182(Suppl 1):S103-S107, 2000.
  117. L.A. Davidson, R.E. Brown, W.C. Chang, J.R. Lupton, J.S. Morris, N. Wang, R.J. Carroll, N.D. Turner and R.S. Chapkin. Morphodensitometric analysis of protein kinase CbII expression in rat colon: modulation by diet and relation to in situ cell proliferation and apoptosis. Carcinogenesis 21:1513-1519, 2000.
  118. R.S. Chapkin,Y.Y. Fan and J.R. Lupton. Effect of diet on colonic programmed cell death: molecular mechanism of action. Toxicology Letters 112-113, 411-414, 2000.
  119. M.Y. Hong, R.S. Chapkin, J.S. Morris, N. Wang, R.J. Carroll, N.D. Turner and J.R. Lupton. Relationship between DNA adduct levels, repair enzyme and apoptosis as a function of DNA alkylation by azoxymethane. Cell Growth & Differentiation 10:749-758, 1999.
  120. A.P. Fields and R.S. Chapkin. Signaling to colon cancer. Gastroenterology 7:1499-1500, 1999.
  121. J.R. Lupton, W.C.L. Chang, M.Y. Hong and R.S. Chapkin. Fat/fiber interactions on colonic cytokinetics: Relationship to colon cancer. Asia Pacific Journal of Clinical Nutrition.(Suppl.) S37-S40, 1999.
  122. Y.Y. Fan, N. Turner, J. Zhang, R. Barhoumi, R.C. Burghardt, J.R. Lupton and R.S. Chapkin. Antagonism of CD95 (APO-1/Fas) signaling blocks butyrate induction of apoptosis in young adult mouse colonic (YAMC) cells. American Journal of Physiology: 277 (Cell Physiology 46): C310-C319, 1999.
  123. N.R. Murray, L.A. Davidson, R.S. Chapkin, W.C. Gustafson, D.G. Schattenberg and A.P. Fields. Overexpression of protein kinase C beta II in the colonic epithelium causes hyperproliferation and increased sensitivity to colon carcinogenesis. Journal of Cell Biology. 145:699-711, 1999.
  124. L.A. Davidson, J.R. Lupton, Y.H. Jiang and R.S. Chapkin. Carcinogen and dietary lipid regulate ras expression and localization in rat colon without affecting farnesylation kinetics. Carcinogenesis 20:785-791, 1999.
  125. R.S. Chapkin, A.E. Clark, L.A. Davidson, F. Schroeder and J.R. Lupton. Dietary fiber differentially alters cellular fatty acid binding protein expression in exfoliated colonocytes during tumor development. Nutrition and Cancer 32:107-112, 1998.
  126. J. Zhang, G. Wu, R.S. Chapkin and J.R. Lupton. Energy metabolism of colonocytes changes during the tumorigenesis process and is dependent on diet and carcinogen. Journal of Nutrition 128:1262-1269, 1998.
  127. C.A. Jolly, D.N. McMurray and R.S. Chapkin. Effect of dietary n-3 fatty acids on interleukin-2, interleukin-2 receptor a expression in activated murine lymphocytes. Prostaglandins, Leukotrienes and Essential Fatty Acids 58:289-293, 1998.
  128. L.A. Davidson, C.M. Aymond, Y.H. Jiang, N.D. Turner, J.R. Lupton and R.S. Chapkin. Noninvasive detection of fecal protein kinase CbII and z messenger RNA: Putative biomarkers for colon cancer. Carcinogenesis 19:253-257, 1998.
  129. W.C.L. Chang, R.S. Chapkin and J.R. Lupton. Fish oil blocks azoxymethane-induced tumorigenesis by increased cell differentiation and apoptosis rather than decreased cell proliferation. Journal of Nutrition 128:491-497, 1998.
  130. D.L. Zoran, N.D. Turner, S.S. Taddeo, R.S. Chapkin and J.R. Lupton. Wheat bran reduces tumor incidence in a rodent model of colon cancer independent of effects on distal luminal butyrate concentrations. Journal of Nutrition 127:2217-2225, 1997.
  131. Y.H. Jiang, J.R. Lupton and R.S. Chapkin. Chemopreventive effects of dietary fat and fiber on azoxymethane-induced alterations in colonic PKC lambda expression. Journal of Nutrition 127:1938-1943, 1997.
  132. T.J. Weber, Y.Y. Fan, R.S. Chapkin and K.S. Ramos. Growth-related signaling in vascular smooth muscle cells is deregulated by TCDD during G0/G1 transition. Journal of Toxicology and Environmental Health 51:369-386, 1997.
  133. Y.Y. Fan, K.S. Ramos and R.S. Chapkin. Dietary gamma-linolenic acid enhances release of macrophage-derived prostaglandin E1 leading to inhibition of mouse vascular smooth muscle cell proliferation. Journal of Nutrition 127:1765-1771, 1997.
  134. W.-C.L. Chang, R.S. Chapkin and J.R. Lupton. Predictive value of proliferation, differentiation and apoptosis as intermediate markers for colon tumorigenesis. Carcinogenesis 18:721-730, 1997.
  135. M.W. Hong, W.-C.L. Chang, R.S. Chapkin and J.R. Lupton. Relationship between colonocyte proliferation, differentiation and apoptosis as a function of diet and carcinogen. Nutrition and Cancer 28:20-29, 1997.
  136. K.G. Maciorowski, J.R. Lupton, R.S. Chapkin, C.L. Shermer, S.D. Ha and S.C. Ricke. The effect of diet and carcinogen on colonic microbial populations in rats. Journal of Nutrition 127:449-457, 1997.
  137. Y.H. Jiang, J.R. Lupton and R.S. Chapkin. Dietary fish oil blocks carcinogen-induced down-regulation of colonic protein kinase C isozymes. Carcinogenesis 18:351-357, 1997.
  138. D.L. Zoran, R. Barhoumi, R.C. Burghardt, R.S. Chapkin and J.R. Lupton. Diet and carcinogen alter luminal butyrate concentration and intracellular pH in isolated rat colonocytes. Nutrition and Cancer 27:222-230, 1997.
  139. C.A. Jolly, Y.H. Jiang, R.S. Chapkin and D.N. McMurray. Dietary n-3 polyunsaturated fatty acid modulation of murine lymphoproliferation and interleukin-2 secretion: Correlation with alterations in diacylglycerol and ceramide mass. Journal of Nutrition 127:37-43, 1997.
  140. H.M. Aukema, L.A. Davidson, B.C. Pence, Y.H. Jiang, J.R. Lupton and R.S. Chapkin. Butyrate alters activity of specific cAMP-receptor proteins in a transgenic mouse colonic cell line. Journal of Nutrition 127:18-24, 1997.
  141. Y.Y. Fan, R.S. Chapkin and K.S. Ramos. Dietary lipid source alters macrophage/vascular smooth muscle cell interactions in vitro. Journal of Nutrition 126:2083-2088, 1996.
  142. K.S. Ramos, Y. Zhang, D.N. Sadhu and R.S. Chapkin. The induction of proliferative vascular smooth muscle cell phenotypes by benzo (a) pyrene is characterized by up-regulation of inositol phospholipid metabolism and c-Ha-ras gene expression. Archives of Biochemistry and Biophysics 332:213-222, 1996.
  143. Y.H. Jiang, J.R. Lupton, C.A. Jolly, L.A. Davidson, H.M. Aukema and R.S. Chapkin. Dietary fat and fiber differentially regulate intracellular second messengers during tumor development in rat colon. Carcinogenesis 17:1227-1233, 1996.
  144. T.J. Weber, R.S. Chapkin, L.A. Davidson and K.S. Ramos. Modulation of protein kinase C (PKC)-related signal transduction by 2,3,7,8-tetrachlorodibenzo-p-dioxin exhibits cell cycle-dependence. Archives of Biochemistry and Biophysics 328:227-232, 1996.
  145. Y.Y. Fan, K.S. Ramos and R.S. Chapkin. Cell cycle-dependent inhibition of DNA synthesis in vascular smooth muscle cells by prostaglandin E1: Relationship to intracellular cAMP levels. Prostaglandins, Leukotrienes and Essential Fatty Acids. 54:101-107, 1996.
  146. C.A. Jolly, J.C. Laurenz, D.N. McMurray and R.S. Chapkin. Diacylglycerol and ceramide kinetics in primary cultures of activated T-lymphocytes. Immunology Letters 49:43-48, 1996.
  147. Y.H. Jiang, L.A. Davidson, J.R. Lupton and R.S. Chapkin. Rapid competitive PCR determination of relative gene expression in limiting tissue samples. Clinical Chemistry 42:227-231, 1996.
  148. J.C. Laurenz, J.M. Gunn, C.A. Jolly and R.S. Chapkin. Alteration of glycerolipid and sphingolipid-derived second messenger kinetics in ras transformed 3T3 cells. Biochimica et Biophysica Acta 1299:146-154, 1996.
  149. Y.H. Jiang, H.M. Aukema, L.A. Davidson, J.R. Lupton and R.S. Chapkin. Localization of protein kinase C isozymes in rat colon. Cell Growth & Differentiation 6:1381-1386, 1995.
  150. L.A. Davidson, Y.-H. Jiang, J.R. Lupton and R.S. Chapkin. Non-invasive detection of putative biomarkers for colon cancer using fecal mRNA. Cancer Epidemiology, Biomarkers and Prevention 4:643-647, 1995.
  151. Y.H. Jiang, L.A. Davidson, J.R. Lupton and R.S. Chapkin. A rapid RT-PCR method for detection of intact RNA in formalin-fixed paraffin-embedded tissues. Nucleic Acids Research 23:3071-3072, 1995.
  152. Y.Y. Fan, K.S. Ramos and R.S. Chapkin. Dietary gammalinolenic acid modulates macrophage-vascular smooth muscle cell interactions: Evidence for a macrophage-derived soluble factor which downregulates DNA synthesis in smooth muscle cells. Arteriosclerosis, Thrombosis and Vascular Biology 15:1397-1403, 1995.
  153. Y.Y. Fan, R.S. Chapkin and K.S. Ramos. A macrophage-smooth muscle cell co-culture model: Applications in the study of atherogenesis. In Vitro Cellular and Developmental Biology 31:492-493, 1995.
  154. J.B. Carrick, J.N. Moore, R.S. Chapkin and R.G. Schnellmann. Thioglycollate elicitation increases phospholipid arachidonic acid content, decreases eicosanoid synthesis and increases TNF synthesis by rat peritoneal macrophages. Shock 3:284-291, 1995.
  155. J.S. Pickering, J.R. Lupton and R.S. Chapkin. Dietary fat, fiber and carcinogen alter fecal diacylglycerol composition and mass. Cancer Research 55:2293-2298, 1995.
  156. X. Ou, R.S. Chapkin and K.S. Ramos. Interference with PKC-related mitogenic signal transduction by benzo (a) pyrene is associated with inhibition of quail aortic smooth muscle cell proliferation. Archives of Biochemistry and Biophysics 318:122-130, 1995.
  157. H.M. Aukema, T. Yamaguichi, K. Tomobe, D.J. Philbrick, R.S. Chapkin, H. Takahashi and B.J. Holub. Diet and disease alter phosphoinositide composition and metabolism in murine polycystic kidneys. Journal of Nutrition 125:1183-1191, 1995.
  158. L.A. Davidson, J.R. Lupton, J.H. Jiang, W.C. Chang, H.M. Aukema and R.S. Chapkin. Dietary fat and fiber alter rat colon protein kinase C isozyme expression. Journal of Nutrition 125:49-56, 1995.
  159. H.M. Aukema, L.A. Davidson, J.R. Lupton and R.S. Chapkin. Diet modulation of rat colonic cAMP-dependent protein kinase activity. Biochemica et Biophysica Acta 1224:51-60, 1994.
  160. N.E. Hubbard, R.S. Chapkin and K.L.Erickson.Effect of inseed oil on tumoricidal activity and altered eicosanoid production in murine macrophages.Lipids 29:651-655, 1994.
  161. L.A. Davidson, Y.H. Jiang, J.N. Derr, H.M. Aukema, J.R. Lupton and R.S. Chapkin. Protein kinase C isoforms in human and rat colonic mucosa. Archives of Biochemistry and Biophysics 312:547-553, 1994.
  162. K.H. Fowler, D.N. McMurray, Y.Y. Fan, H.M. Aukema and R.S. Chapkin. Purified dietary n-3 polyunsaturated fatty acids alter diacylglycerol mass and molecular species composition in concanavalin A stimulated murine splenocytes. Biochimica et Biophysica Acta 1210:89-96, 1993.
  163. D.Y. Lee, J.R. Lupton, H.M. Aukema and R.S. Chapkin. Dietary fat and fiber alter rat colonic mucosal lipid mediators and cell proliferation. Journal of Nutrition 123:1808-1817, 1993.
  164. K.H. Fowler, R.S. Chapkin, and D.N. McMurray. Effects of purified dietary n-3 ethyl esters on murine T-lymphocyte function. Journal of Immunology 151:5186-5197, 1993.
  165. Y.Y. Fan and R.S. Chapkin. Phospholipid sources of metabolically elongated gammalinolenic acid: Conversion to prostaglandin E1 in stimulated mouse macrophages. Journal of Nutritional Biochemistry 4:602-607, 1993.
  166. D.Y.K. Lee, R.S. Chapkin and J.R. Lupton. Dietary fat and fiber modulate colonic cell proliferation in an interactive site specific manner. Nutrition and Cancer 20:107-118, 1993.
  167. E. Berra, M.T. Diaz-Meco, I. Dominguez, M.M. Municio, L. Sanz, J. Lozano, R.S. Chapkin and J. Moscat. Protein kinase C zeta isoform is critical for mitogenic signal transduction. Cell 74:555-563, 1993.
  168. D.C. Gaudette, H.M. Aukema, C.A. Jolly, R.S. Chapkin and B.J. Holub. Mass and fatty acid composition of the 3-phosphorylated PIP2 isomer in stimulated human platelets. Journal of Biological Chemistry 268:13773-13776, 1993.
  169. D.E. Barre, B.J. Holub and R.S. Chapkin. The effect of borage oil supplementation on human platelet aggregation, thromboxane B2, prostaglandin E1 and E2 formation. Nutrition Research 13:739-751, 1993.
  170. R.S. Chapkin, J. Gao, D-Y K. Lee, and J.R. Lupton. Effect of dietary fibers and fats on rat colon protein kinase C activity: Correlation to cell proliferation. Journal of Nutrition 123:649-655, 1993.
  171. H. Aukema, R.S. Chapkin, K. Tomobe, H. Takahashi and B.J. Holub. In vivo detection of phosphatidylinositol-3-phosphate and association with polycystic renal disease. Experimental & Molecular Pathology 57:39-46, 1992.
  172. R.S. Chapkin, C.C. Akoh and R.E. Lewis. Dietary fish oil modulation of in vivo peritoneal macrophage leukotriene production and phagocytosis. Journal of Nutritional Biochemistry 3:599-604, 1992.
  173. R.S. Chapkin, L.D. Davidson and L.A. Davidson. Phospholipid molecular species composition of mouse liver nuclei: Influence of dietary n-3 fatty acid ethyl esters. Biochemical Journal 287:237-240, 1992.
  174. Y.Y. Fan and R.S. Chapkin. Enhancement of mouse peritoneal macrophage prostaglandin E1 by dietary gamma-linolenic acid. Journal of Nutrition 122:1600-1606, 1992.
  175. D.Y. Lee, J.R. Lupton and R.S. Chapkin. Prostaglandin profile and synthetic capacity of the colon: Comparison of tissue sources and subcellular fractions. Prostaglandins 43:143-164, 1992.
  176. R.S. Chapkin and K.J. Coble. Utilization of gammalinolenic acid by mouse peritoneal macrophages. Biochimica et Biophysica Acta 1085:365-370, 1991.
  177. R.S. Chapkin, C.C. Akoh and C.C. Miller. Influence of dietary n-3 fatty acids on macrophage glycerophospholipid molecular species and peptido leukotriene synthesis. Journal of Lipid Research 32:1205-1213, 1991.
  178. R.S. Chapkin and K.J. Coble. Remodeling of mouse kidney phospholipid classes and subclasses by diet. Journal of Nutritional Biochemistry 2:158-164, 1991.
  179. R.S. Chapkin and S.L. Carmichael. Effects of dietary n-3 and n-6 polyunsaturated fatty acids on macrophage phospholipid classes and subclasses. Lipids 25:827-834, 1990.
  180. C.C. Akoh and R.S. Chapkin. Composition of mouse peritoneal macrophage phospholipid molecular species. Lipids 25:613-617, 1990.
  181. R.S. Chapkin, N.E. Hubbard and K.L. Erickson. 5-series peptido-leukotriene synthesis in mouse peritoneal macrophages: Modulation by dietary n-3 fatty acids. Biochemical and Biophysical Research Communications 171:764-769, 1990.
  182. R.S. Chapkin and S.L. Carmichael. Effect of dietary blackcurrant seed oil on macrophage subclasses of choline and ethanolamine glycerophospholipids. Journal of Nutrition 120:825-830, 1990.
  183. D.K. Buckman, R.S. Chapkin, and K.L. Erickson. Modulation of mouse mammary tumor growth and linoleic acid enhanced metastasis by oleic acid. Journal of Nutrition 120:148-157, 1990.
  184. R.S. Chapkin and C.C. Miller. Chain elongation of eicosapentaenoic acid in the macrophage. Biochimica et Biophysica Acta 1042:265-267, 1990.
  185. S.D. Somers, R.S. Chapkin and K.L. Erickson. Alteration of in vitro murine peritoneal macrophage function by dietary enrichment with eicosapentaenoic acid and docosahexaenoic acids in menhaden fish oil. Cellular Immunology 123:201-211, 1989.
  186. R.S. Chapkin, N.E. Hubbard, D.K. Buckman and K.L. Erickson. Linoleic acid metabolism in metastatic and nonmetastatic murine mammary tumor cells. Cancer Research 49:4724-4728, 1989.
  187. N.E. Hubbard, R.S. Chapkin and K.L. Erickson. Inhibition of linoleate-enhanced metastasis of a transplantable mouse mammary tumor by indomethacin. Cancer Letters 43:111-120, 1988.
  188. R.S. Chapkin, S.D. Somers and K.L. Erickson. Dietary manipulation of macrophage phospholipid classes: Selective increase of dihomogammalinolenic acid. Lipids 23:766-770, 1988.
  189. R.S. Chapkin, C.C. Miller, S.D. Somers and K.L. Erickson. Ability of monohydroxyeicosatrienoic acid (15-OH-20:3) to modulate macrophage arachidonic acid metabolism. Biochemical and Biophysical Research Communications 153:799-804, 1988.
  190. R.S. Chapkin, S.D. Somers and K.L. Erickson. Inability of murine peritoneal macrophages to convert linoleic acid into arachidonic acid: Evidence of chain elongation. Journal of Immunology 140:2350-2355, 1988.
  191. R.S. Chapkin, C.C. Miller, S.D. Somers and K.L. Erickson. Utilization of dihomogammalinolenic acid (8,11,14-eicosatrienoic acid) by murine peritoneal macrophages. Biochimica et Biophysica Acta 959:322-331, 1988.
  192. R.S. Chapkin, S.D. Somers, L. Schumacher and K.L. Erickson. Fatty acid composition of macrophage phospholipids in mice fed fish or borage oil. Lipids 23:380-383, 1988.
  193. V.A. Ziboh and R.S. Chapkin. Biologic significance of polyunsaturated fatty acids in the skin. Archives of Dermatology 123:1686a-1690, 1987.
  194. R.R. Isseroff, V.A. Ziboh, R.S. Chapkin and D.T. Martinez. Conversion of exogenous linoleic acid into arachidonic acid by cultured murine and human keratinocytes: Evidence for an alternate pathway. Journal of Lipid Research 28:1342-1349, 1987.
  195. R.S. Chapkin, V.A. Ziboh and J.L. McCullough. Dietary influences of evening primrose and fish oils on skin of essential fatty acid deficient guinea pigs. Journal of Nutrition 117:1360-1370, 1987.
  196. R.S. Chapkin and V.A. Ziboh. Metabolism of essential fatty acids by human epidermal enzyme preparations: Evidence of chain elongation. Journal of Lipid Research. 27:945-954, 1986.
  197. R.S. Chapkin and V.A. Ziboh. Inability of skin enzyme preparations to biosynthesize arachidonic acid from linoleic acid. Biochemical and Biophysical Research Communications 124(3):784-792, 1984.
  198. R.S. Chapkin, B. Haberstroh, T. Liu and B.J. Holub. Effect of vitamin E supplementation on serum and high-density lipoprotein-cholesterol in renal patients on maintenance hemodialysis. American Journal of Clinical Nutrition 38:253-256, 1983.
  199. R.S. Chapkin, B. Haberstroh, T. Liu and B.J. Holub. Characterization of the individual phospholipids and their fatty acids in serum and high-density lipoproteins of the renal patient on long term maintenance hemodialysis. Journal of Laboratory and Clinical Medicine 101:726-735, 1983.
  200. L.U. Thompson, K. Boland, R.S. Chapkin and J.D. Jones. Nutritional evaluation of residual meal from rapeseed protein concentration process in rats. Nutrition Reports International 25(4):621-628, 1982.
  201. R.S. Chapkin, Nysia I George1, Joanne R Lupton, Nancy D Turner, Laurie A Davidson, Naisyin Wang. Evaluation of fecal mRNA reproducibility via a marginal transformed mixture modeling approach.Download
  202. R.S. Chapkin,Chen Zhao,Ivan Ivanov,Edward R. Dougherty,Terryl J. Hartman,Elaine Lanza,Gerd Bobe, Nancy H. Colburn,Joanne R. Lupton,Laurie A. Davidson. Noninvasive Detection of Candidate Molecular Biomarkers in Subjects with a History of Insulin Resistance and Colorectal Adenomas.Download
  203. R.S. Chapkin,Diana L. Bonilla, Yang-Yi Fan and David N. McMurray. Transgenic Mice Enriched in Omega-3 Fatty Acids Are More Susceptible to Pulmonary Tuberculosis:Impaired Resistance to Tuberculosis in fat-1 Mice.Download
  204. R.S. Chapkin,Laurie A. Davidson, Naisyin Wang, Ivan Ivanov, Jennifer Goldsby,Joanne R. Lupton. Identification of Actively Translated mRNA Transcripts in a Rat Model of Early-Stage Colon Carcinogenesis.Download
  205. R.S. Chapkin,Valerian E. Kagan1, Ayse Bayir1, Hulya Bayir1, Detcho Stoyanovsky, Grigory G. Borisenko1, Yulia Y. Tyurina1, Peter Wipf, Jeffrey Atkinson, Joel S. Greenberger1, and Natalia A. Belikova. Mitochondria-targeted disruptors and inhibitors of cytochrome c/ cardiolipin peroxidase complexes: A new strategy in anti-apoptotic drug discovery.Download
  206. R.S. Chapkin,Wooki Kim , DavidN.McMurray. n-3 Polyunsaturatedfattyacids—Physiological relevanceofdose.Download
  207. R.S. Chapkin,Wooki Kim, Naim A. Khan, David N. McMurray , Ian A. Prior , Naisyin Wang. Regulatory activity of polyunsaturated fatty acids in T-cell signaling.Download
  208. W. Kim, D.N. McMurray and R.S. Chapkin. n-3 polyunsaturated fatty acids – physiological relevance and dose. Prostaglandins Leukotrienes & Essential Fatty Acids (In press).