Assistant Professor, MMPA
College of Medicine
Texas A&M Health Science Center
Another research theme in the lab focuses on membrane vesicles (MVs): discrete spherical nano-assemblies produced from the outer membrane by Gram-negative bacteria. Although described in the literature for decades, the mechanism of production and MV function(s) have only begun to be clarified. In preliminary studies using Salmonella, we demonstrated MVs have potent adjuvant and immunogenic properties for pathogen-specific humoral and cell-mediated host defense stimulation in vivo. After vaccination, MVs induce protective immunity in mice against subsequent live Salmonella challenge, unlike that reported for heat-inactivated bacteria.
T-cell, DC, mucosal immunology, microbiota, metabolites, inflammatory disorders.