Publications By Year

2017

Yoshihama S, Vijayan S, Sidiq, T, Kobayashi, KS.
NLRC5/CITA: a key player in cancer immune surveillance.
Trends Cancer. 2017 Jan;3(1):28-38.

Pandey, A, Ding, S L, Qin, Q-M, Gupta, R, Gomez, G, Lin, F, Feng, X, da Costa, LF, Chaki, SP, Katepalli, M, Case, ED, van Schaik, EJ, Sidiq, T, Khalaf, O, Arenas, A, Kobayashi, KS, Samuel, JE, Rivera, GM, Alaniz, RC, Sze, S-H, Qian, X, Brown, WJ, Rice-Ficht, A, Russell, WK, Ficht, TA, and de Figueiredo, P.
Global Reprogramming of Host Kinase Signaling in Response to Fungal Infection.
Cell Host Micro. 2017 May 10;21(5):637-649.

Bist, P, Cheong, WS, Ng, A, Dikshit, N, Kim, BH, Pulloor, N, Khameneh, HJ, Matija Hedl, Shenoy, A, Balamuralidhar, V, Malik, N., Hong, M, Neutzner, A, Chin, K-C, Kobayashi, KS, Bertoletti, A, Mortellaro, A, Abraham, C, MacMicking, J, Xavier, R, and Sukumaran B.
E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP.
Nat Commun 2017 Jun 28;8:15865.

 

2016

Sidiq, T, Yoshihama, S, Downs, I, Kobayashi, KS.
Nod2: a critical regulator of ileal microbiota and Crohn’s disease.
Front Immunol, 2016 Sep 20;7:367.

Yoshihama S, Roszik J, Downs I, Meissner TB, Vijayan S, Chapuy B, Sidiq T, Shipp MA, Lizee GA, Kobayashi KS.
NLRC5/MHC class I transactivator is a target for immune evasion in cancer.
Proc Natl Acad Sci U S A. 2016 May 24;113(21):5999-6004.

Downs I, Vijayan S, Sidiq T, Kobayashi KS.
CITA/NLRC5: A critical transcriptional regulator of MHC class I gene expression.
Biofactors. 2016 Apr 18.

 

2015

Burrows MP, Volchkov P, Kobayashi KS, Chervonsky AV.
Microbiota regulates type 1 diabetes through Toll-like receptors.
Proc Natl Acad Sci U S A. 2016 May 24;113(21):5999-6004.

Shiu J, Piazuelo MB, Ding H, Czinn SJ, Drakes ML, Banerjee A, Basappa N, Kobayashi KS, Fricke WF, Blanchard TG.
Gastric LTi cells promote lymphoid follicle formation but are limited by IRAK-M and do not alter microbial growth.
Mucosal Immunol. 2015 Sep;8(5):1047-59

Miyata M, Lee JY, Susuki-Miyata S, Wang WY, Xu H, Kai H, Kobayashi KS, Flavell RA, Li JD.
Glucocorticoids suppress inflammation via the upregulation of negative regulator IRAK-M.
Nat Commun. 2015 Jan 14;6:6062.

 

2014

Lech M, Gröbmayr R, Ryu M, Lorenz G, Hartter I, Mulay SR, Susanti HE, Kobayashi KS, Flavell RA, Anders HJ.
Macrophage phenotype controls long-term AKI outcomes–kidney regeneration versus atrophy.
J Am Soc Nephrol. 2014 Feb;25(2):292-304.

 

2013

Shiu J, Czinn SJ, Kobayashi KS, Sun Y, Blanchard TG.
IRAK-M expression limits dendritic cell activation and proinflammatory cytokine production in response to Helicobacter pylori.
PLoS One. 2013 Jun 11;8(6):e66914.

Klimesova K, Kverka M, Zakostelska Z, Hudcovic T, Hrncir T, Stepankova R, Rossmann P, Ridl J, Kostovcik M, Mrazek J, Kopecny J, Kobayashi KS, Tlaskalova-Hogenova H.
Altered gut microbiota promotes colitis-associated cancer in IL-1 receptor-associated kinase M-deficient mice.
Inflamm Bowel Dis. 2013 May;19(6):1266-77.

Mingueneau M, Kreslavsky T, Gray D, Heng T, Cruse R, Ericson J, Bendall S, Spitzer MH, Nolan GP, Kobayashi K, von Boehmer H, Mathis D, Benoist C; Immunological Genome Consortium, Best AJ, Knell J, Goldrath A, Joic V, Koller D, Shay T, Regev A, Cohen N, Brennan P, Brenner M, Kim F, Nageswara Rao T, Wagers A, Heng T, Ericson J, Rothamel K, Ortiz-Lopez A, Mathis D, Benoist C, Bezman NA, Sun JC, Min-Oo G, Kim CC, Lanier LL, Miller J, Brown B, Merad M, Gautier EL, Jakubzick C, Randolph GJ, Monach P, Blair DA, Dustin ML, Shinton SA, Hardy RR, Laidlaw D, Collins J, Gazit R, Rossi DJ, Malhotra N, Sylvia K, Kang J, Kreslavsky T, Fletcher A, Elpek K, Bellemare-Pelletier A, Malhotra D, Turley S.
The transcriptional landscape of αβ T cell differentiation.
Nat Immunol. 2013 Jun;14(6):619-32. doi: 10.1038/ni.2590. Epub 2013 May 5. PMID: 23644507

Biswas A, Kobayashi KS.
Regulation of intestinal microbiota by the NLR protein family.
Int Immunol. 2013 Apr;25(4):207-14. 

2012

Kobayashi KS, van den Elsen PJ.
NLRC5: a key regulator of MHC class I-dependent immune responses.
Nat Rev Immunol. 2012 Dec;12(12):813-20.

Lee KH, Biswas A, Liu YJ, Kobayashi KS.
Proteasomal degradation of Nod2 protein mediates tolerance to bacterial cell wall components.
J Biol Chem. 2012 Nov 16;287(47):39800-11.

Sukumaran B, Ogura Y, Pedra JH, Kobayashi KS, Flavell RA, Fikrig E.
Receptor interacting protein-2 contributes to host defense against Anaplasma phagocytophilum infection.
FEMS Immunol Med Microbiol. 2012 Nov;66(2):211-9.

Hoogerwerf JJ, van der Windt GJ, Blok DC, Hoogendijk AJ, De Vos AF, van ‘t Veer C, Florquin S, Kobayashi KS, Flavell RA, van der Poll T.
Interleukin-1 receptor-associated kinase M-deficient mice demonstrate an improved host defense during Gram-negative pneumonia.
Mol Med. 2012 Sep 25;18:1067-75.

Koo JE, Hong HJ, Dearth A, Kobayashi KS, Koh YS.
Intracellular invasion of Orientia tsutsugamushi activates inflammasome in asc-dependent manner.
PLoS One. 2012;7(6):e39042.

Biswas A, Meissner TB, Kawai T, Kobayashi KS.
Cutting edge: impaired MHC class I expression in mice deficient for Nlrc5/class I transactivator.
J Immunol. 2012 Jul 15;189(2):516-20.

NOD2 signaling contributes to host defense in the lungs against Escherichia coli infection.
Theivanthiran B, Batra S, Balamayooran G, Cai S, Kobayashi K, Flavell RA, Jeyaseelan S.
Infect Immun. 2012 Jul;80(7):2558-69.

van der Windt GJ, Blok DC, Hoogerwerf JJ, Lammers AJ, de Vos AF, Van’t Veer C, Florquin S, Kobayashi KS, Flavell RA, van der Poll T.
Interleukin 1 receptor-associated kinase m impairs host defense during pneumococcal pneumonia.
J Infect Dis. 2012 Jun 15;205(12):1849-57.

Meissner TB, Liu YJ, Lee KH, Li A, Biswas A, van Eggermond MC, van den Elsen PJ, Kobayashi KS.
NLRC5 cooperates with the RFX transcription factor complex to induce MHC class I gene expression.
J Immunol. 2012 May 15;188(10):4951-8.

Meissner TB, Li A, Liu YJ, Gagnon E, Kobayashi KS.
The nucleotide-binding domain of NLRC5 is critical for nuclear import and transactivation activity.
Biochem Biophys Res Commun. 2012 Feb 24;418(4):786-91.

Meissner TB, Li A, Kobayashi KS.
NLRC5: a newly discovered MHC class I transactivator (CITA).
Microbes Infect. 2012 Jun;14(6):477-84.

Kobayashi KS.
NLRC5/CITA: a novel regulator of class I major histocompatibility complex genes.
J immunodefic Disord. 2012;1(1). pii: 1000e102.

Delhase M, Kim SY, Lee H, Naiki-Ito A, Chen Y, Ahn ER, Murata K, Kim SJ, Lautsch N, Kobayashi KS, Shirai T, Karin M, Nakanishi M.
TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2.
Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):E177-86. 

Zhao Y, Alonso C, Ballester I, Song JH, Chang SY, Guleng B, Arihiro S, Murray PJ, Xavier R, Kobayashi KS, Reinecker HC.
Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1.
Inflamm Bowel Dis. 2012 Apr;18(4):603-12. 

2011

Ogawa C, Liu YJ, Kobayashi KS.
Muramyl dipeptide and its derivatives: peptide adjuvant in immunological disorders and cancer therapy.
Curr Bioact Compd. 2011 Sep;7(3):180-197.

Caetano BC, Biswas A, Lima DS Jr, Benevides L, Mineo TW, Horta CV, Lee KH, Silva JS, Gazzinelli RT, Zamboni DS, Kobayashi KS.
Intrinsic expression of Nod2 in CD4+ T lymphocytes is not necessary for the development of cell-mediated immunity and host resistance to Toxoplasma gondii.
Eur J Immunol. 2011 Dec;41(12):3627-31.

Lech M, Kantner C, Kulkarni OP, Ryu M, Vlasova E, Heesemann J, Anz D, Endres S, Kobayashi KS, Flavell RA, Martin J, Anders HJ.
Interleukin-1 receptor-associated kinase-M suppresses systemic lupus erythematosus.
Ann Rheum Dis. 2011 Dec;70(12):2207-17.

Biswas A, Petnicki-Ocwieja T, Kobayashi KS.
Nod2: a key regulator linking microbiota to intestinal mucosal immunity.
J Mol Med (Berl). 2012 Jan;90(1):15-24.

Balamayooran T, Batra S, Balamayooran G, Cai S, Kobayashi KS, Flavell RA, Jeyaseelan S.
Receptor-interacting protein 2 controls pulmonary host defense to Escherichia coli infection via the regulation of interleukin-17A.
Infect Immun. 2011 Nov;79(11):4588-99.

Petnicki-Ocwieja T, DeFrancesco AS, Chung E, Darcy CT, Bronson RT, Kobayashi KS, Hu LT.
Nod2 suppresses Borrelia burgdorferi mediated murine Lyme arthritis and carditis through the induction of tolerance.
PLoS One. 2011 Feb 28;6(2):e17414.

Biswas A, Wilmanski J, Forsman H, Hrncir T, Hao L, Tlaskalova-Hogenova H, Kobayashi KS.
Negative regulation of Toll-like receptor signaling plays an essential role in homeostasis of the intestine.
Eur J Immunol. 2011 Jan;41(1):182-94.

Lee KH, Liu YJ, Biswas A, Ogawa C, Kobayashi KS.
A novel aminosaccharide compound blocks immune responses by Toll-like receptors and nucleotide-binding domain, leucine-rich repeat proteins.
J Biol Chem. 2011 Feb 18;286(7):5727-35. 

2010

Berglund M, Melgar S, Kobayashi KS, Flavell RA, Hörnquist EH, Hultgren OH.
IL-1 receptor-associated kinase M downregulates DSS-induced colitis.
Inflamm Bowel Dis. 2010 Oct;16(10):1778-86.

Frutuoso MS, Hori JI, Pereira MS, Junior DS, Sônego F, Kobayashi KS, Flavell RA, Cunha FQ, Zamboni DS.
The pattern recognition receptors Nod1 and Nod2 account for neutrophil recruitment to the lungs of mice infected with Legionella pneumophila.
Microbes Infect. 2010 Oct;12(11):819-27.

Biswas A, Liu YJ, Hao L, Mizoguchi A, Salzman NH, Bevins CL, Kobayashi KS.
Induction and rescue of Nod2-dependent Th1-driven granulomatous inflammation of the ileum.
Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14739-44.

Koh YS, Koo JE, Biswas A, Kobayashi KS.
MyD88-dependent signaling contributes to host defense against ehrlichial infection.
PLoS One. 2010 Jul 23;5(7):e11758.

Meissner TB, Li A, Biswas A, Lee KH, Liu YJ, Bayir E, Iliopoulos D, van den Elsen PJ, Kobayashi KS.
NLR family member NLRC5 is a transcriptional regulator of MHC class I genes.
Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13794-9.

Hubbard LL, Ballinger MN, Thomas PE, Wilke CA, Standiford TJ, Kobayashi KS, Flavell RA, Moore BB.
A role for IL-1 receptor-associated kinase-M in prostaglandin E2-induced immunosuppression post-bone marrow transplantation.
J Immunol. 2010 Jun 1;184(11):6299-308.

Charrière GM, Ip WE, Dejardin S, Boyer L, Sokolovska A, Cappillino MP, Cherayil BJ, Podolsky DK, Kobayashi KS, Silverman N, Lacy-Hulbert A, Stuart LM.
Identification of Drosophila Yin and PEPT2 as evolutionarily conserved phagosome-associated muramyl dipeptide transporters.
J Biol Chem. 2010 Jun 25;285(26):20147-54.

Archer KA, Ader F, Kobayashi KS, Flavell RA, Roy CR.
Cooperation between multiple microbial pattern recognition systems is important for host protection against the intracellular pathogen Legionella pneumophila.
Infect Immun. 2010 Jun;78(6):2477-87.

Silva GK, Gutierrez FR, Guedes PM, Horta CV, Cunha LD, Mineo TW, Santiago-Silva J, Kobayashi KS, Flavell RA, Silva JS, Zamboni DS.
Cutting edge: nucleotide-binding oligomerization domain 1-dependent responses account for murine resistance against Trypanosoma cruzi infection.
J Immunol. 2010 Feb 1;184(3):1148-52.

2009

Petnicki-Ocwieja T, Hrncir T, Liu YJ, Biswas A, Hudcovic T, Tlaskalova-Hogenova H, Kobayashi KS.

Nod2 is required for the regulation of commensal microbiota in the intestine.
Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15813-8.

Matza D, Badou A, Jha MK, Willinger T, Antov A, Sanjabi S, Kobayashi KS, Marchesi VT, Flavell RA.
Requirement for AHNAK1-mediated calcium signaling during T lymphocyte cytolysis.
Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9785-90.

Sicard P, Jacquet S, Kobayashi KS, Flavell RA, Marber MS.
Pharmacological postconditioning effect of muramyl dipeptide is mediated through RIP2 and TAK1.
Cardiovasc Res. 2009 Jul 15;83(2):277-84.

Rosenzweig HL, Jann MM, Glant TT, Martin TM, Planck SR, van Eden W, van Kooten PJ, Flavell RA, Kobayashi KS, Rosenbaum JT, Davey MP.
Activation of nucleotide oligomerization domain 2 exacerbates a murine model of proteoglycan-induced arthritis.
J Leukoc Biol. 2009 Apr;85(4):711-8.

2008

Shin S, Case CL, Archer KA, Nogueira CV, Kobayashi KS, Flavell RA, Roy CR, Zamboni DS.
Type IV secretion-dependent activation of host MAP kinases induces an increased proinflammatory cytokine response to Legionella pneumophila.
PLoS Pathog. 2008 Nov;4(11):e1000220.

Divangahi M, Mostowy S, Coulombe F, Kozak R, Guillot L, Veyrier F, Kobayashi KS, Flavell RA, Gros P, Behr MA.
NOD2-deficient mice have impaired resistance to Mycobacterium tuberculosis infection through defective innate and adaptive immunity.
J Immunol. 2008 Nov 15;181(10):7157-65.

Rosenzweig HL, Martin TM, Planck SR, Galster K, Jann MM, Davey MP, Kobayashi K, Flavell RA, Rosenbaum JT.
Activation of NOD2 in vivo induces IL-1beta production in the eye via caspase-1 but results in ocular inflammation independently of IL-1 signaling.
J Leukoc Biol. 2008 Aug;84(2):529-36.

Rosenzweig HL, Martin TM, Jann MM, Planck SR, Davey MP, Kobayashi K, Flavell RA, Rosenbaum JT.
NOD2, the gene responsible for familial granulomatous uveitis, in a mouse model of uveitis.
Invest Ophthalmol Vis Sci. 2008 Apr;49(4):1518-24.

Jacquet S, Nishino Y, Kumphune S, Sicard P, Clark JE, Kobayashi KS, Flavell RA, Eickhoff J, Cotten M, Marber MS.
The role of RIP2 in p38 MAPK activation in the stressed heart.
J Biol Chem. 2008 May 2;283(18):11964-71.

Matza D, Badou A, Kobayashi KS, Goldsmith-Pestana K, Masuda Y, Komuro A, McMahon-Pratt D, Marchesi VT, Flavell RA.
A scaffold protein, AHNAK1, is required for calcium signaling during T cell activation.
Immunity. 2008 Jan;28(1):64-74.

Wilmanski JM, Petnicki-Ocwieja T, Kobayashi KS.
NLR proteins: integral members of innate immunity and mediators of inflammatory diseases.
J Leukoc Biol. 2008 Jan;83(1):13-30.

2007

Pan Q, Mathison J, Fearns C, Kravchenko VV, Da Silva Correia J, Hoffman HM, Kobayashi KS, Bertin J, Grant EP, Coyle AJ, Sutterwala FS, Ogura Y, Flavell RA, Ulevitch RJ.
MDP-induced interleukin-1beta processing requires Nod2 and CIAS1/NALP3.
J Leukoc Biol. 2007 Jul;82(1):177-83.

2006

Deng JC, Cheng G, Newstead MW, Zeng X, Kobayashi K, Flavell RA, Standiford TJ.
Sepsis-induced suppression of lung innate immunity is mediated by IRAK-M.
J Clin Invest. 2006 Sep;116(9):2532-42.

Pan Q, Kravchenko V, Katz A, Huang S, Ii M, Mathison JC, Kobayashi K, Flavell RA, Schreiber RD, Goeddel D, Ulevitch RJ.
NF-kappa B-inducing kinase regulates selected gene expression in the Nod2 signaling pathway.
Infect Immun. 2006 Apr;74(4):2121-7.

Shinohara ML, Lu L, Bu J, Werneck MB, Kobayashi KS, Glimcher LH, Cantor H.
Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells.
Nat Immunol. 2006 May;7(5):498-506.

Zamboni DS, Kobayashi KS, Kohlsdorf T, Ogura Y, Long EM, Vance RE, Kuida K, Mariathasan S, Dixit VM, Flavell RA, Dietrich WF, Roy CR.
The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection.
Nat Immunol. 2006 Mar;7(3):318-25.

2005

Li H, Cuartas E, Cui W, Choi Y, Crawford TD, Ke HZ, Kobayashi KS, Flavell RA, Vignery A.
IL-1 receptor-associated kinase M is a central regulator of osteoclast differentiation and activation.
J Exp Med. 2005 Apr 4;201(7):1169-77.

Kobayashi KS, Chamaillard M, Ogura Y, Henegariu O, Inohara N, Nuñez G, Flavell RA.
Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract.
Science. 2005 Feb 4;307(5710):731-4.