2016
Tripathi DN, Zhang J, Jing J, Dere R & Walker CL (2016) A new role for ATM in selective autophagy of peroxisomes (pexophagy). Autophagy 12:711-712. PMID: 27050462
Tripathi DN & Walker CL (2016) The peroxisome as a cell signaling organelle. Curr Opin Cell Biol 39:109-112. PMID: 26967755
McCampbell AS, Mittelstadt ML, Dere R, Kim S, Zhou L, Djordjevic B, Soliman PT, Zhang Q, Wei C, Hursting SD, Lu KH, Broaddus RR, & Walker CL (2016) Loss of p27 Associated with Risk for Endometrial Carcinoma Arising in the Setting of Obesity. Curr Mol Med 16(3):252-265. PMID: 26917264
Klionsky DJ, and ~2000 co-authors, including Walker CL (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12(1):1-222. PMID: 26799652
Ho TH, Park IY, Zhao H, Tong P, Champion MD, Yan H, Monzon FA, Hoang A, Tamboli P, Parker AS, Joseph RW, Qiao W, Dykema K, Tannir NM, Castle EP, Nunez-Nateras R, Teh BT, Wang J, Walker CL, Hung MC, & Jonasch E (2016) High-resolution profiling of histone h3 lysine 36 trimethylation in metastatic renal cell carcinoma. Oncogene 35(12):1565-1574. PMID: 26073078
2015
Zhou L, Liu XD, Sun M, Zhang X, German P, Bai S, Ding Z, Tannir N, Wood CG, Matin SF, Karam JA, Tamboli P, Sircar K, Rao P, Rankin EB, Laird DA, Hoang AG, Walker CL, Giaccia AJ, & Jonasch E (2015) Targeting MET and AXL overcomes resistance to sunitinib therapy in renal cell carcinoma. Oncogene. PMID: 26364599
Zhang J, Tripathi DN, Jing J, Alexander A, Kim J, Powell RT, Dere R, Tait-Mulder J, Lee JH, Paull TT, Pandita RK, Charaka VK, Pandita TK, Kastan MB, & Walker CL (2015) ATM functions at the peroxisome to induce pexophagy in response to ROS. Nat Cell Biol 17(10):1259-1269. PMID: 26344566
Wong RL, Wang Q, Trevino LS, Bosland MC, Chen J, Medvedovic M, Prins GS, Kannan K, Ho SM, & Walker CL (2015) Identification of secretaglobin Scgb2a1 as a target for developmental reprogramming by BPA in the rat prostate. Epigenetics 10(2):127-134. PMID: 25612011
Trevino LS, Wang Q, & Walker CL (2015) Phosphorylation of epigenetic “readers, writers and erasers”: Implications for developmental reprogramming and the epigenetic basis for health and disease. Prog Biophys Mol Biol 118(1-2):8-13. PMID: 25841987
Trevino LS, Wang Q, & Walker CL (2015) Hypothesis: Activation of rapid signaling by environmental estrogens and epigenetic reprogramming in breast cancer. Reprod Toxicol 54:136-140. PMID: 25554384
Sahin K, Cross B, Sahin N, Ciccone K, Suleiman S, Osunkoya AO, Master V, Harris W, Carthon B, Mohammad R, Bilir B, Wertz K, Moreno CS, Walker CL, & Kucuk O (2015) Lycopene in the prevention of renal cell cancer in the TSC2 mutant Eker rat model. Arch Biochem Biophys 572:36-39. PMID: 25602702
Liu XD, Yao J, Tripathi DN, Ding Z, Xu Y, Sun M, Zhang J, Bai S, German P, Hoang A, Zhou L, Jonasch D, Zhang X, Conti CJ, Efstathiou E, Tannir NM, Eissa NT, Mills GB, Walker CL, & Jonasch E (2015) Autophagy mediates HIF2alpha degradation and suppresses renal tumorigenesis. Oncogene 34(19):2450-2460.
Jing J, He L, Sun A, Quintana A, Ding Y, Ma G, Tan P, Liang X, Zheng X, Chen L, Shi X, Zhang SL, Zhong L, Huang Y, Dong MQ, Walker CL, Hogan PG, Wang Y, & Zhou Y (2015) Proteomic mapping of ER-PM junctions identifies STIMATE as a regulator of Ca(2)(+) influx. Nat Cell Biol 17(10):1339-1347. PMID: 26322679
Grandjean P, Barouki R, Bellinger DC, Casteleyn L, Chadwick LH, Cordier S, Etzel RA, Gray KA, Ha EH, Junien C, Karagas M, Kawamoto T, Paige Lawrence B, Perera FP, Prins GS, Puga A, Rosenfeld CS, Sherr DH, Sly PD, Suk W, Sun Q, Toppari J, van den Hazel P, Walker CL, & Heindel JJ (2015) Life-Long Implications of Developmental Exposure to Environmental Stressors: New Perspectives. Endocrinology 156(10):3408-3415.
Dere R, Perkins AL, Bawa-Khalfe T, Jonasch D, & Walker CL (2015) beta-catenin links von Hippel-Lindau to aurora kinase A and loss of primary cilia in renal cell carcinoma. J Am Soc Nephrol 26(3):553-564. PMID: 25313256
2014
Stossi F, Bolt MJ, Ashcroft FJ, Lamerdin JE, Melnick JS, Powell RT, Dandekar RD, Mancini MG, Walker CL, Westwick JK, & Mancini MA (2014) Defining estrogenic mechanisms of bisphenol A analogs through high throughput microscopy-based contextual assays. Chem Biol 21(6):743-753.
Prins GS, Hu WY, Shi GB, Hu DP, Majumdar S, Li G, Huang K, Nelles JL, Ho SM, Walker CL, Kajdacsy-Balla A, & van Breemen RB (2014) Bisphenol A promotes human prostate stem-progenitor cell self-renewal and increases in vivo carcinogenesis in human prostate epithelium. Endocrinology 155(3):805-817.
Martin TD, Chen XW, Kaplan RE, Saltiel AR, Walker CL, Reiner DJ, & Der CJ (2014) Ral and Rheb GTPase activating proteins integrate mTOR and GTPase signaling in aging, autophagy, and tumor cell invasion. Mol Cell 53(2):209-220.
2013
Zhang J, Kim J, Alexander A, Cai S, Tripathi DN, Dere R, Tee AR, Tait-Mulder J, Di Nardo A, Han JM, Kwiatkowski E, Dunlop EA, Dodd KM, Folkerth RD, Faust PL, Kastan MB, Sahin M, & Walker CL (2013) A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS. Nat Cell Biol 15(10):1186-1196.
Wong RL & Walker CL (2013) Molecular pathways: environmental estrogens activate nongenomic signaling to developmentally reprogram the epigenome. Clin Cancer Res 19(14):3732-3737.
Tripathi DN, Chowdhury R, Trudel LJ, Tee AR, Slack RS, Walker CL, & Wogan GN (2013) Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1. Proc Natl Acad Sci U S A 110(32):E2950-2957.
Peng H, Liu J, Sun Q, Chen R, Wang Y, Duan J, Li C, Li B, Jing Y, Chen X, Mao Q, Xu KF, Walker CL, Li J, Wang J, & Zhang H (2013) mTORC1 enhancement of STIM1-mediated store-operated Ca2+ entry constrains tuberous sclerosis complex-related tumor development. Oncogene 32(39):4702-4711.
2012
Walker CL & Ho SM (2012) Developmental reprogramming of cancer susceptibility. Nat Rev Cancer 12(7):479-486.
Klionsky DJ, 1269 co-authors, including Walker CL (2012) Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 8(4):445-544.
Kim J, Otto N, Conti CJ, Gimenz-Conti IB, & Walker CL (2012) Immunohistochemical analysis of mTOR activity in tissues. Methods Mol Biol 821:215-225.
Jonasch E, Futreal PA, Davis IJ, Bailey ST, Kim WY, Brugarolas J, Giaccia AJ, Kurban G, Pause A, Frydman J, Zurita AJ, Rini BI, Sharma P, Atkins MB, Walker CL, & Rathmell WK (2012) State of the science: an update on renal cell carcinoma. Mol Cancer Res 10(7):859-880.
Greathouse KL, Bredfeldt T, Everitt JI, Lin K, Berry T, Kannan K, Mittelstadt ML, Ho SM, & Walker CL (2012) Environmental estrogens differentially engage the histone methyltransferase EZH2 to increase risk of uterine tumorigenesis. Mol Cancer Res 10(4):546-557.
2011
Walker CL (2011) Epigenomic reprogramming of the developing reproductive tract and disease susceptibility in adulthood. Birth Defects Res A Clin Mol Teratol 91(8):666-671.
Itamochi H, Yoshida T, Walker CL, Bartholomeusz C, Aoki D, Ishihara H, Suzuki N, Kigawa J, Terakawa N, & Ueno NT (2011) Novel mechanism of reduced proliferation in ovarian clear cell carcinoma cells: cytoplasmic sequestration of CDK2 by p27. Gynecol Oncol 122(3):641-647.
Alexander A & Walker CL (2011) The role of LKB1 and AMPK in cellular responses to stress and damage. FEBS Lett 585(7):952-957.
2010
Short JD, Dere R, Houston KD, Cai SL, Kim J, Bergeron JM, Shen J, Liang J, Bedford MT, Mills GB, & Walker CL (2010) AMPK-mediated phosphorylation of murine p27 at T197 promotes binding of 14-3-3 proteins and increases p27 stability. Mol Carcinog 49(5):429-439.
McCampbell AS, Harris HA, Crabtree JS, Winneker RC, Walker CL, & Broaddus RR (2010) Loss of inhibitory insulin receptor substrate-1 phosphorylation is an early event in mammalian target of rapamycin-dependent endometrial hyperplasia and carcinoma. Cancer Prev Res (Phila) 3(3):290-300.
McCampbell AS, Broaddus RR, & Walker CL (2010) Loss of inhibitory insulin receptor substrate-1 phosphorylation: An early event in endometrial hyperplasia and progression to carcinoma. Cell Cycle 9(14):2698-2699.
Dere R, Wilson PD, Sandford RN, & Walker CL (2010) Carboxy terminal tail of polycystin-1 regulates localization of TSC2 to repress mTOR. PLoS One 5(2):e9239.
Bredfeldt TG, Greathouse KL, Safe SH, Hung MC, Bedford MT, & Walker CL (2010) Xenoestrogen-induced regulation of EZH2 and histone methylation via estrogen receptor signaling to PI3K/AKT. Mol Endocrinol 24(5):993-1006.
Alexander A & Walker CL (2010) Differential localization of ATM is correlated with activation of distinct downstream signaling pathways. Cell Cycle 9(18):3685-3686.
Alexander A, Kim J, & Walker CL (2010) ATM engages the TSC2/mTORC1 signaling node to regulate autophagy. Autophagy 6(5):672-673.
Alexander A, Cai SL, Kim J, Nanez A, Sahin M, MacLean KH, Inoki K, Guan KL, Shen J, Person MD, Kusewitt D, Mills GB, Kastan MB, & Walker CL (2010) ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. Proc Natl Acad Sci U S A 107(9):4153-4158.
2009
Yu JJ, Robb VA, Morrison TA, Ariazi EA, Karbowniczek M, Astrinidis A, Wang C, Hernandez-Cuebas L, Seeholzer LF, Nicolas E, Hensley H, Jordan VC, Walker CL, & Henske EP (2009) Estrogen promotes the survival and pulmonary metastasis of tuberin-null cells. Proc Natl Acad Sci U S A 106(8):2635-2640.
Kim J, Jonasch E, Alexander A, Short JD, Cai S, Wen S, Tsavachidou D, Tamboli P, Czerniak BA, Do KA, Wu KJ, Marlow LA, Wood CG, Copland JA, & Walker CL (2009) Cytoplasmic sequestration of p27 via AKT phosphorylation in renal cell carcinoma. Clin Cancer Res 15(1):81-90.
Crabtree JS, Jelinsky SA, Harris HA, Choe SE, Cotreau MM, Kimberland ML, Wilson E, Saraf KA, Liu W, McCampbell AS, Dave B, Broaddus RR, Brown EL, Kao W, Skotnicki JS, Abou-Gharbia M, Winneker RC, & Walker CL (2009) Comparison of human and rat uterine leiomyomata: identification of a dysregulated mammalian target of rapamycin pathway. Cancer Res 69(15):6171-6178.
Blando J, Portis M, Benavides F, Alexander A, Mills G, Dave B, Conti CJ, Kim J, & Walker CL (2009) PTEN deficiency is fully penetrant for prostate adenocarcinoma in C57BL/6 mice via mTOR-dependent growth. Am J Pathol 174(5):1869-1879.
2008
Woodruff TK & Walker CL (2008) Fetal and early postnatal environmental exposures and reproductive health effects in the female. Fertil Steril 89(2 Suppl):e47-51.
Wei C, Amos CI, Zhang N, Wang X, Rashid A, Walker CL, Behringer RR, & Frazier ML (2008) Suppression of Peutz-Jeghers polyposis by targeting mammalian target of rapamycin signaling. Clin Cancer Res 14(4):1167-1171.
Short JD, Houston KD, Dere R, Cai SL, Kim J, Johnson CL, Broaddus RR, Shen J, Miyamoto S, Tamanoi F, Kwiatkowski D, Mills GB, & Walker CL (2008) AMP-activated protein kinase signaling results in cytoplasmic sequestration of p27. Cancer Res 68(16):6496-6506.
McCampbell AS, Walker CL, Broaddus RR, Cook JD, & Davies PJ (2008) Developmental reprogramming of IGF signaling and susceptibility to endometrial hyperplasia in the rat. Lab Invest 88(6):615-626.
Lu KH, Wu W, Dave B, Slomovitz BM, Burke TW, Munsell MF, Broaddus RR, & Walker CL (2008) Loss of tuberous sclerosis complex-2 function and activation of mammalian target of rapamycin signaling in endometrial carcinoma. Clin Cancer Res 14(9):2543-2550.
Isobe A, Takeda T, Sakata M, Miyake A, Yamamoto T, Minekawa R, Nishimoto F, Oskamoto Y, Walker CL, & Kimura T (2008) Dual repressive effect of angiotensin II-type 1 receptor blocker telmisartan on angiotensin II-induced and estradiol-induced uterine leiomyoma cell proliferation. Hum Reprod 23(2):440-446.
Greathouse KL, Cook JD, Lin K, Davis BJ, Berry TD, Bredfeldt TG, & Walker CL (2008) Identification of uterine leiomyoma genes developmentally reprogrammed by neonatal exposure to diethylstilbestrol. Reprod Sci 15(8):765-778.
2007
Ptacek T, Song C, Walker CL, & Sell SM (2007) Physical mapping of distinct 7q22 deletions in uterine leiomyoma and analysis of a recently annotated 7q22 candidate gene. Cancer Genet Cytogenet 174(2):116-120.
Liang J, Shao SH, Xu ZX, Hennessy B, Ding Z, Larrea M, Kondo S, Dumont DJ, Gutterman JU, Walker CL, Slingerland JM, & Mills GB (2007) The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis. Nat Cell Biol 9(2):218-224.
Laping NJ, Everitt JI, Frazier KS, Burgert M, Portis MJ, Cadacio C, Gold LI, & Walker CL (2007) Tumor-specific efficacy of transforming growth factor-beta RI inhibition in Eker rats. Clin Cancer Res 13(10):3087-3099.
Hall WC, Elder B, Walker CL, Cai SL, Peters DG, Goodman DG, Ulland BM, & Borzelleca JF (2007) Spontaneous renal tubular hyperplastic and neoplastic lesions in three Sprague-Dawley rats from a 90-day toxicity study. Toxicol Pathol 35(2):233-241.
Cook JD, Davis BJ, Goewey JA, Berry TD, & Walker CL (2007) Identification of a sensitive period for developmental programming that increases risk for uterine leiomyoma in Eker rats. Reprod Sci 14(2):121-136.
2006 and Before
Walker CL, Whitby L, Granger V, Storie I, Reilly JT, & Barnett D (2006) Flow rate calibration. III. The use of stabilized biostandards to calibrate the flow rate and calculate absolute CD4+ T-cell counts. Cytometry B Clin Cytom 70(3):154-162.
Mally A, Walker CL, Everitt JI, Dekant W, & Vamvakas S (2006) Analysis of renal cell transformation following exposure to trichloroethene in vivo and its metabolite S-(dichlorovinyl)-L-cysteine in vitro. Toxicology 224(1-2):108-118.
Cai SL & Walker CL (2006) TSC2, a key player in tumor suppression and cystic kidney disease. Nephrol Ther 2 Suppl 2:S119-122.
Cai SL, Tee AR, Short JD, Bergeron JM, Kim J, Shen J, Guo R, Johnson CL, Kiguchi K, & Walker CL (2006) Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning. J Cell Biol 173(2):279-289.
Walker CL & Stewart EA (2005) Uterine fibroids: the elephant in the room. Science 308(5728):1589-1592.
Cook JD, Davis BJ, Cai SL, Barrett JC, Conti CJ, & Walker CL (2005) Interaction between genetic susceptibility and early-life environmental exposure determines tumor-suppressor-gene penetrance. Proc Natl Acad Sci U S A 102(24):8644-8649.
Kleymenova E, Everitt JI, Pluta L, Portis M, Gnarra JR, & Walker CL (2004) Susceptibility to vascular neoplasms but no increased susceptibility to renal carcinogenesis in Vhl knockout mice. Carcinogenesis 25(3):309-315.
Cook JD & Walker CL (2004) The Eker rat: establishing a genetic paradigm linking renal cell carcinoma and uterine leiomyoma. Curr Mol Med 4(8):813-824.
Cook JD & Walker CL (2004) Treatment strategies for uterine leiomyoma: the role of hormonal modulation. Semin Reprod Med 22(2):105-111.
Walker CL, Hunter D, & Everitt JI (2003) Uterine leiomyoma in the Eker rat: a unique model for important diseases of women. Genes Chromosomes Cancer 38(4):349-356.
Liu MY, Poellinger L, & Walker CL (2003) Up-regulation of hypoxia-inducible factor 2alpha in renal cell carcinoma associated with loss of Tsc-2 tumor suppressor gene. Cancer Res 63(10):2675-2680.
Lee S, Walker CL, & Wevrick R (2003) Prader-Willi syndrome transcripts are expressed in phenotypically significant regions of the developing mouse brain. Gene Expr Patterns 3(5):599-609.
Houston KD, Copland JA, Broaddus RR, Gottardis MM, Fischer SM, & Walker CL (2003) Inhibition of proliferation and estrogen receptor signaling by peroxisome proliferator-activated receptor gamma ligands in uterine leiomyoma. Cancer Res 63(6):1221-1227.
Hodges LC, Cook JD, Lobenhofer EK, Li L, Bennett L, Bushel PR, Aldaz CM, Afshari CA, & Walker CL (2003) Tamoxifen functions as a molecular agonist inducing cell cycle-associated genes in breast cancer cells. Mol Cancer Res 1(4):300-311.
Finlay GA, Hunter DS, Walker CL, Paulson KE, & Fanburg BL (2003) Regulation of PDGF production and ERK activation by estrogen is associated with TSC2 gene expression. Am J Physiol Cell Physiol 285(2):C409-418.
Cesen-Cummings K, Houston KD, Copland JA, Moorman VJ, Walker CL, & Davis BJ (2003) Uterine leiomyomas express myometrial contractile-associated proteins involved in pregnancy-related hormone signaling. J Soc Gynecol Investig 10(1):11-20.
Cai S, Everitt JI, Kugo H, Cook J, Kleymenova E, & Walker CL (2003) Polycystic kidney disease as a result of loss of the tuberous sclerosis 2 tumor suppressor gene during development. Am J Pathol 162(2):457-468.
Burke TW & Walker CL (2003) Arzoxifene as therapy for endometrial cancer. Gynecol Oncol 90(2 Pt 2):S40-46.
Yoon HS, Monks TJ, Everitt JI, Walker CL, & Lau SS (2002) Cell proliferation is insufficient, but loss of tuberin is necessary, for chemically induced nephrocarcinogenicity. Am J Physiol Renal Physiol 283(2):F262-270.
Walker CL (2002) Role of hormonal and reproductive factors in the etiology and treatment of uterine leiomyoma. Recent Prog Horm Res 57:277-294.
Liu MY, Cai S, Espejo A, Bedford MT, & Walker CL (2002) 14-3-3 interacts with the tumor suppressor tuberin at Akt phosphorylation site(s). Cancer Res 62(22):6475-6480.
Kugoh H, Kleymenova E, & Walker CL (2002) Retention of membrane-localized beta-catenin in cells lacking functional polycystin-1 and tuberin. Mol Carcinog 33(3):131-136.
Irani C, Goncharova EA, Hunter DS, Walker CL, Panettieri RA, & Krymskaya VP (2002) Phosphatidylinositol 3-kinase but not tuberin is required for PDGF-induced cell migration. Am J Physiol Lung Cell Mol Physiol 282(4):L854-862.
Hunter DS, Klotzbucher M, Kugoh H, Cai SL, Mullen JP, Manfioletti G, Fuhrman U, & Walker CL (2002) Aberrant expression of HMGA2 in uterine leiomyoma associated with loss of TSC2 tumor suppressor gene function. Cancer Res 62(13):3766-3772.
Hodges LC, Houston KD, Hunter DS, Fuchs-Young R, Zhang Z, Wineker RC, & Walker CL (2002) Transdominant suppression of estrogen receptor signaling by progesterone receptor ligands in uterine leiomyoma cells. Mol Cell Endocrinol 196(1-2):11-20.
Goncharova EA, Goncharov DA, Eszterhas A, Hunter DS, Glassberg MK, Yeung RS, Walker CL, Noonan D, Kwiatkowski DJ, Chou MM, Panettieri RA, Jr., & Krymskaya VP (2002) Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM). J Biol Chem 277(34):30958-30967.
KD, Howe SR, Okubo Y, Fuchs-Young R, LeRoith D, & Walker CL (2002) Dysregulation of IGF-I signaling in uterine leiomyoma. J Endocrinol 172(1):83-93.
Astrinidis A, Cash TP, Hunter DS, Walker CL, Chernoff J, & Henske EP (2002) Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration. Oncogene 21(55):8470-8476.
Yoon HS, Monks TJ, Walker CL, & Lau SS (2001) Transformation of kidney epithelial cells by a quinol thioether via inactivation of the tuberous sclerosis-2 tumor suppressor gene. Mol Carcinog 31(1):37-45.
Xu H, Shen J, Walker CL, & Kleymenova E (2001) Tissue-specific expression and splicing of the rat polycystic kidney disease 1 gene. DNA Seq 12(5-6):361-366.
Walker CL, Cesen-Cummings K, Houle C, Baird D, Barrett JC, & Davis B (2001) Protective effect of pregnancy for development of uterine leiomyoma. Carcinogenesis 22(12):2049-2052.
Lau SS, Yoon HS, Patel SK, Everitt JI, Walker CL, & Monks TJ (2001) Mutagenicity and carcinogenicity of biological reactive intermediate’s derived from a “non-genotoxic” carcinogen. Adv Exp Med Biol 500:83-92.
Lau SS, Monks TJ, Everitt JI, Kleymenova E, & Walker CL (2001) Carcinogenicity of a nephrotoxic metabolite of the “nongenotoxic” carcinogen hydroquinone. Chem Res Toxicol 14(1):25-33.
Kleymenova E & Walker CL (2001) Determination of loss of heterozygosity in frozen and paraffin embedded tumors by denaturating high-performance liquid chromatography (DHPLC). J Biochem Biophys Methods 47(1-2):83-90.
Houston KD, Hunter DS, Hodges LC, & Walker CL (2001) Uterine leiomyomas: mechanisms of tumorigenesis. Toxicol Pathol 29(1):100-104.
Hodges LC, Hunter DS, Bergerson JS, Fuchs-Young R, & Walker CL (2001) An in vivo/in vitro model to assess endocrine disrupting activity of xenoestrogens in uterine leiomyoma. Ann N Y Acad Sci 948:100-111.
Walker CL, Burroughs KD, Davis B, Sowell K, Everitt JI, & Fuchs-Young R (2000) Preclinical evidence for therapeutic efficacy of selective estrogen receptor modulators for uterine leiomyoma. J Soc Gynecol Investig 7(4):249-256.
Perera AD, Kleymenova EV, & Walker CL (2000) Requirement for the von Hippel-Lindau tumor suppressor gene for functional epidermal growth factor receptor blockade by monoclonal antibody C225 in renal cell carcinoma. Clin Cancer Res 6(4):1518-1523.
Kleymenova E, Muga S, Fischer S, & Walker CL (2000) Application of high-performance liquid chromatography-based analysis of DNA fragments to molecular carcinogenesis. Mol Carcinog 29(2):51-58.
Hunter DS, Hodges LC, Eagon PK, Vonier PM, Fuchs-Young R, Bergerson JS, & Walker CL (2000) Influence of exogenous estrogen receptor ligands on uterine leiomyoma: evidence from an in vitro/in vivo animal model for uterine fibroids. Environ Health Perspect 108 Suppl 5:829-834.
Hodges LC, Bergerson JS, Hunter DS, & Walker CL (2000) Estrogenic effects of organochlorine pesticides on uterine leiomyoma cells in vitro. Toxicol Sci 54(2):355-364.
Gamage SD, Bischoff ED, Burroughs KD, Lamph WW, Gottardis MM, Walker CL, & Fuchs-Young R (2000) Efficacy of LGD1069 (Targretin), a retinoid X receptor-selective ligand, for treatment of uterine leiomyoma. J Pharmacol Exp Ther 295(2):677-681.
Cesen-Cummings K, Walker CL, & Davis BJ (2000) Lessons from pregnancy and parturition: uterine leiomyomas result from discordant differentiation and dedifferentiation responses in smooth muscle cells. Med Hypotheses 55(6):485-490.
Cesen-Cummings K, Copland JA, Barrett JC, Walker CL, & Davis BJ (2000) Pregnancy, parturition, and prostaglandins: defining uterine leiomyomas. Environ Health Perspect 108 Suppl 5:817-820.
Burroughs KD, Fuchs-Young R, Davis B, & Walker CL (2000) Altered hormonal responsiveness of proliferation and apoptosis during myometrial maturation and the development of uterine leiomyomas in the rat. Biol Reprod 63(5):1322-1330.
Kleymenova EV, Declue JE, & Walker CL (1999) Genetic variants of the tuberous sclerosis 2 tumour suppressor gene in mouse t haplotypes. Genet Res 74(2):139-144.
Johnson DG & Walker CL (1999) Cyclins and cell cycle checkpoints. Annu Rev Pharmacol Toxicol 39:295-312.
Hunter DS, Hodges LC, Vonier PM, Fuchs-Young R, Gottardis MM, & Walker CL (1999) Estrogen receptor activation via activation function 2 predicts agonism of xenoestrogens in normal and neoplastic cells of the uterine myometrium. Cancer Res 59(13):3090-3099.
Davies JA, Perera AD, & Walker CL (1999) Mechanisms of epithelial development and neoplasia in the metanephric kidney. Int J Dev Biol 43(5):473-478.
Rennebeck G, Kleymenova EV, Anderson R, Yeung RS, Artzt K, & Walker CL (1998) Loss of function of the tuberous sclerosis 2 tumor suppressor gene results in embryonic lethality characterized by disrupted neuroepithelial growth and development. Proc Natl Acad Sci U S A 95(26):15629-15634.
Kleymenova EV, Yuan X, LaBate ME, & Walker CL (1998) Identification of a tumor-specific methylation site in the Wilms tumor suppressor gene. Oncogene 16(6):713-720.
Kleymenova EV, Bianchi AA, Kley N, Pylev LN, & Walker CL (1997) Characterization of the rat neurofibromatosis 2 gene and its involvement in asbestos-induced mesothelioma. Mol Carcinog 18(1):54-60.
Everitt JI, Walker CL, Goldsworthy TW, & Wolf DC (1997) Altered expression of transforming growth factor-alpha: an early event in renal cell carcinoma development. Mol Carcinog 19(3):213-219.
Walker CL (1996) Cancer susceptibility genes and molecular carcinogenesis. American Association for Cancer Research Special Conference: Cancer Susceptibility Genes and Molecular Carcinogenesis. Mol Med Today 2(9):364-365.
Pass HI, Mew DJ, Carbone M, Matthews WA, Donington JS, Baserga R, Walker CL, Resnicoff M, & Steinberg SM (1996) Inhibition of hamster mesothelioma tumorigenesis by an antisense expression plasmid to the insulin-like growth factor-1 receptor. Cancer Res 56(17):4044-4048.
Yeung RS, Xiao GH, Everitt JI, Jin F, & Walker CL (1995) Allelic loss at the tuberous sclerosis 2 locus in spontaneous tumors in the Eker rat. Mol Carcinog 14(1):28-36.
Rutten AA, Bermudez E, Stewart W, Everitt JI, & Walker CL (1995) Expression of insulin-like growth factor II in spontaneously immortalized rat mesothelial and spontaneous mesothelioma cells: a potential autocrine role of insulin-like growth factor II. Cancer Res 55(16):3634-3639.
Knapek DF, Serrano M, Beach D, Trono D, & Walker CL (1995) Association of rat p15INK4B/p16INK4 deletions with monosomy 5 in kidney epithelial cell lines but not primary renal tumors. Cancer Res 55(8):1607-1612.
Everitt JI, Goldsworthy TL, Wolf DC, & Walker CL (1995) Hereditary renal cell carcinoma in the Eker rat: a unique animal model for the study of cancer susceptibility. Toxicol Lett 82-83:621-625.
Aldaz CM, Yeung RS, Latif F, Lerman MI, Xiao G, Trono D, & Walker CL (1995) Colocalization of the rat homolog of the von Hippel Lindau (Vhl) gene and the plasma membrane Ca++ transporting ATPase isoform 2 (Atp2b2) gene to rat chromosome bands 4q41.3–>42.1. Cytogenet Cell Genet 71(3):253-256.
Bermudez E, Chen Z, Gross EA, Walker CL, Recio L, Pluta L, & Morgan KT (1994) Characterization of cell lines derived from formaldehyde-induced nasal tumors in rats. Mol Carcinog 9(4):193-199.
Everitt JI, Goldsworthy TL, Wolf DC, & Walker CL (1992) Hereditary renal cell carcinoma in the Eker rat: a rodent familial cancer syndrome. J Urol 148(6):1932-1936.
Nettesheim P, Fitzgerald DJ, Kitamura H, Walker CL, Gilmer TM, Barrett JC, & Gray TE (1987) In vitro analysis of multistage carcinogenesis. Environ Health Perspect 75:71-79.