Lymphatic Physiology of Multi-Tissue Systems
Manipulating lymphatic endothelial cell biology to uncover novel functions for lymphatic physiology in health and disease.
Lymphatic capillaries maintain tissue homeostasis. Lymphatics (green) and blood vessels (red) make up the tissue’s microcirculation. This image from the skin shows how the vessels are densely intermingled.
Lymphatic circulation as a critical regulator of tissues homeostasis. Lymphatic vessel functions are particularly important during inflammation. We are interested both in how lymphatic physiology is impacted by disease and in how manipulating lymphatic biology or inducing lymphangiogenesis may prevent or reduce tissue pathologies. Our research approach incorporates a vast array of tools from protein analysis and lipidomics to tissue engineering and transgenic mouse model generation. Current projects are focused on the pathophysiology of chronic diseases such as obesity, diabetes, lipedema, hypertension, and kidney disease.