Lymphatic Physiology of Multi-Tissue Systems

Lymphatic Physiology of Multi-Tissue Systems

Manipulating lymphatic endothelial cell biology to uncover novel functions for lymphatic physiology in health and disease.

Lymphangioblasts forming a hyperplastic network
Lymphatic vasculogenesis in white adipose tissue

Lymphangioblasts forming new lymphatic structures in VEGF-D over-expressing brown adipose tissue.

Lymphatic circulation as a critical regulator of tissues homeostasis. Lymphatic vessel functions are particularly important during inflammation. We are interested both in how lymphatic physiology is impacted by disease and in how manipulating lymphatic biology or inducing lymphangiogenesis may prevent or reduce tissue pathologies. Our research approach incorporates a vast array of tools from protein analysis and lipidomics to tissue engineering and transgenic mouse model generation. Current projects are focused on the pathophysiology of chronic diseases such as obesity, diabetes, lipedema, hypertension, and kidney disease.