Publications

  1. Abbey CA, Coffell A, Duran CL, Chakraborty S, Wells GB, Bayless KJ. Single Cell and bulk RNA sequencing of invading and non-invading sub-populations of endothelial cells reveals AP-1 driven partial EndMT association with angiogenic sprout initiation. Arterioscler Thromb Vasc Biol. 2024 Mar 14. doi: 10.1161/ATVBAHA.123.320599. Online ahead of print. PMID: 38482696.
  2. Creed H, Kannan S, Tate B, Banerjee P, Mitchell B, Chakraborty S, Rutkowski J. Single-cell RNA sequencing identifies response of renal lymphatic endothelial cells to acute kidney injury, J Am Soc Nephrol. 2024 Feb 7. doi: 10.1681/ASN.0000000000000325. Online ahead of print. PMID: 38506705
  3. Maiers JL*, Chakraborty S*. The Cellular, Molecular and Pathological Consequences of Stress on the Liver (2023). American Journal of Pathology. Editorial, Am J Pathol. 2023. Oct;193(10):1353-1354. doi:10.1016/j.ajpath.2023.07.003. Epub 2023 Aug 4. PMID.37544504. (*Corresponding author).
  4. Chakraborty S*, Dixon JB, Rutkowski JM, Castorena-gonzalez J, Breslin J. Lymphatic Pathophysiology (2023). Microcirculation. Editorial. Apr 20; 30 e12806. doi: 10.1111/micc.12806. PMID: 37078170. (*Corresponding author)
  5. Banerjee P,  Gaddam N,  Vanessa C, Chakraborty S (2023). Oxidative Stress-induced liver damage and remodeling of the liver vasculature. Am J Pathol. 2023 Jun 22:S0002-9440(23)00212-2. doi: 10.1016/j.ajpath.2023.06.002. Online ahead of print. PMID: 37355037.
  6. Chakraborty S*, Dixon JB, Rutkowski JM, Castorena-Gonzalez J, Breslin J (2023).Lymphatic Pathophysiology. Microcirculation. Editorial. Apr 20; 30 (2-3) e12806.doi: 10.1111/micc.12806. PMID: 37078170.
  7. Banerjee P,  Subhashree Kumaravel S, Sukanya Roy S, Johnny Odeh J, Gaddam N,  Bayless K, Glaser S, Chakraborty S (2023). Conjugated bile acids promote lymphangiogenesis by modulation of the reactive oxygen species-p90RSK-vascular endothelial growth factor receptor 3 pathway. Cells. Feb 6;12(4):526. doi: 10.3390/cells12040526. PMID: 36831193.
  8. Medford A, Childs J, Little A, Chakraborty S, Baiocchi L, Alpini G and Glaser S (2023). Emerging Therapeutic Strategies in the Fight Against Primary Biliary Cholangitis. JCTH. doi: 10.14218/JCTH.2022.00398
  9. Banerjee P, Gaddam N, Pandita TK, Chakraborty S (2023). Cellular senescence as a brake or accelerator for oncogenic transformation and lymphatic metastasis. Int J Mol Sci Feb 2;24(3):2877. doi: 10.3390/ijms24032877. PMID: 36769195 (Featured Article in Molecular Oncology).
  10. Epigenetic-Metabolic Interplay in the DNA Damage Response and Therapeutic Resistance of Breast Cancer. Cancer Research. Das C, Adhikari S, Bhattacharya A, Chakraborty S, Mondal P, Yadav S, Adhikary S, Hunt C, Yadav K, Pandita S, Roy S, Tainer JA, Ahmed Z, Pandita TK (2023). Mar 2;83(5):657-666. doi: 10.1158/0008-5472.CAN-22-3015.
  11. Kyritsi K, Wu N, Zhou T, Carpino G, Baiocchi L, Kennedy L, Chen L, Ceci L, Meyer A, Barupala N, Franchitto A, Onori P, Ekser B, Gaudio E, Wu C,Marakovits C, Chakraborty S, Francis H, Glaser S, Alpini G (2023). Knockout of secretin ameliorates biliary and liver phenotypes during alcohol induced hepatotoxicity. Cell Biosci. Jan 9;13(1):5. doi: 10.1186/s13578-022-00945. PMID: 36661847.
  12. Little A, Medford A, O’Brien A, Childs J, Pan S, Machado J, Chakraborty S, Glaser S (2022). Recent Advances in Intrahepatic Biliary Epithelial Heterogeneity. Semin Liver Dis. 2022 Dec 15. doi: 10.1055/s-0042-1758833.
  13. Roy S, Banerjee P, Chakraborty S (2022). Recent advancement of imaging strategies of the lymphatic system: Answer to the decades old questions. Microcirculation. Aug 16:e12780. doi: 10.1111/micc.12780. PMID: 35972391.
  14. Wilcox BK, Henley MR, Navaneethabalakrishnan S, Martinez KA, Pournouri A, Goodlett BL, Lopez AH, Allbee ML, Pickup EJ, Bayless KJ, Chakraborty S*, Mitchell BM* (2022). Hypertensive Stimuli Indirectly Stimulate Lymphangiogenesis Through Immune Cell Secreted Factors. Cells. Jul 7;11(14):2139. doi: 10.3390/cells11142139.(* Co-corresponding authors).
  15. Selahi A, Chakraborty S, Muthuchamy M, Zawieja DC, Jain A (2022). Intracellular calcium dynamics of lymphatic endothelial and muscle cells co-cultured in a Lymphangion-Chip under pulsatile flow. Analyst. 2022 Jun 6. doi: 10.1039/d2an00396a.
  16. Yenigun A, Soma D, Aksu E, Lopez K, Park Y, Cross-Najafi A, Li P, Kundu D, House MG, Chakraborty S, Glaser SS, Kennedy L, Francis H, Zhang W, Alpini G, Ekser B (2022). Development and characterization of human primary cholangiocarcinoma cell lines. Am J Pathol May 28:S0002-9440(22)00150-X. doi: 10.1016/j.ajpath.2022.05.007.
  17. Mancinelli R, Ceci L, Kennedy L, Francis H, Meadows V, Chen L, Carpino G, Kyritsi K, Wu N, Zhou T, Sato K, Pannarale L, Glaser S, Chakraborty S, Alpini G, Gaudio E, Onori P, Franchitto A (2022). The effects of taurocholic acid on biliary damage and liver fibrosis are mediated by calcitonin gene related peptide signaling. Cells. May 9;11(9):1591. doi: 10.3390/cells11091591.
  18. Ceci L, Tianhao Z, Lenci I, Meadows V, Kennedy L, Li P, Ekser B, Milana M, Zhang W, Wu C, Sato K, Chakraborty S, Glaser S, Francis H, Alpini G, Baiocchi L (2022). Molecular mechanisms linking risk factors to cholangiocarcinoma development. Cancers, 14(6), 1442; https://doi.org/10.3390/cancers14061442.
  19. Pham L, Kyritsi K, Zhou T, Baiocchi L, Kennedy L, Chakraborty S, Glaser S, Francis H, Alpini G, and Sato K (2022). The functional roles of immune cells in primary liver cancer.  Am J Pathology, https://doi.org/10.1016/j.ajpath.2022.02.004.
  20. O’Brien A, Tianhao Z, Tori W, Abigail M, Lixian C, Konstantina K, Nan W, Childs, Jonathon C, Danaleigh S, Ludovica C, Chakraborty S, Ekser B, Leonardo B, Chaodong W, Kennedy, Lindsey K, Heather F, Gianfranco A, Glaser S (2022). FGF1 signaling modulates biliary injury and liver fibrosis in the Mdr2-/- mouse model of primary sclerosing cholangitis. Hepatology Communications Mar 10. doi: 10.1002/hep4.1909. PMID: 35271760.
  21. Meadows V, Baiocchi L, Kundu D, Sato K, Fuentez Y, Wu C, Chakraborty S, Glaser S, Alpini GD, Kennedy L, Francis H (2021). Biliary Epithelial Senescence in Liver Disease: There Will Be SASP. Front Mol Biosci. Dec 21;8:803098. doi: 10.3389/fmolb.2021.803098. eCollection. PMID: 34993234.
  22. Roy S, Kumaravel S, Banerjee P, White TK, O’Brien A, Seelig C,Chauhan R,Ekser B, Bayless KJ, Alpini G, Glaser S, Chakraborty S (2021). Tumor lymphatic interactions induce CXCR2-CXCL5 axis and alter cellular metabolism and lymphangiogenic pathways to promote cholangiocarcinoma. Cells. Nov 9;10(11):3093. doi: 10.3390/cells10113093.PMID: 34831316.
  23. Selahi A, Fernando T, Chakraborty S, Muthuchamy M, Zawieja DC, Jain A (2021). Lymphangion-chip: a microphysiological system which supports co-culture and bidirectional signaling of lymphatic endothelial and muscle cells. Lab Chip. Dec 1. doi: 10.1039/d1lc00720c. PMID: 34850797.
  24. Roy S, Banerjee P, Ekser B, Bayless KJ, Zawieja DC, Alpini G, Glaser S, Chakraborty S (2021). Targeting lymphangiogenesis and lymph node metastasis in liver cancer.  Am J Pathol. 2021 Sep 9:S0002-9440(21)00384-9. doi: 10.1016/j.ajpath.2021.08.011. Online ahead of print.
  25. Karmakar M,  Lai PC, Sinha S, Glaser S and Chakraborty S (2021). Identification of miR-203a, mir-10a, and miR-194 as predictors for risk of lymphovascular invasion in head and neck cancers. 2021. Oncotarget. 2021 Jul 20;12(15):1499-1519. doi: 10.18632/oncotarget.28022. eCollection 2021 Jul 20. PMID: 34316330.
  26. Zhang X, Chakraborty S, Muthuchamy M, Zawieja DC (2021). Isolation of Lymphatic Muscle Cells (LMCs ) from Rat Mesentery. Methods Mol Biol. 2021;2319:137-141. doi: 10.1007/978-1-0716-1480-8_15. PMID: 34331251.
  27. Baiocchi L, Sato K, Ekser B, Kennedy L, Francis H, Ceci L, Lenci I, Alvaro D, Franchitto A, Onori P, Gaudio E, Wu C, Chakraborty S, Glaser S, Alpini G (2021). Cholangiocarcinoma: Bridging the translational gap from preclinical to clinical development and implications for future therapy. Expert Opin Investig Drugs. 2021 Apr;30(4):365-375. doi: 10.1080/13543784.2021.1854725. Epub 2020 Dec 8. PMID: 33226854.
  28. Zhang X, Chakraborty S, Muthuchamy M, Zawieja DC (2021). Isolation of Lymphatic Muscle Cells (LMCs ) from Rat Mesentery. Methods Mol Biol. 2021;2319:137-141. doi: 10.1007/978-1-0716-1480-8_15. PMID: 34331251
  29. Singh S, Kumaravel S, Dhole S, Roy S, Pawan V, Chakraborty S (2021). Neuropeptide Substance P enhances tumor promoting pathways in head and neck cancers. 2021. In J Surgical Oncology, 2021 Apr;12(Suppl 1):93-102. doi: 10.1007/s13193-020-01210-7. Epub 2020 Sep 1. PMID: 33994734.
  30. Kumaravel S, Duran CL, Bayless KJ, Chakraborty S (2021).The β1 integrin plays a key role in lymphatic endothelial cell invasion in an optimized 3D Collagen matrix model.  2020. Am J Physiol Cell Physiol. 2020 Oct 14. doi: 10.1152/ajpcell.00299.2020. Online ahead of print. PMID: 33052069.
  31. Chen L, Zhou T, White T, O’Brien A, Chakraborty S, Liangpunsakul S, Zhihong Yang Z, Kennedy L, Saxena R, Huang Q, Francis H, Alpini G, Glaser S (2020). The apelin-apelin receptor axis triggers cholangiocyte proliferation and liver fibrosis during cholestasis. 2020. Hepatology, Sep 7 https://doi.org/10.1002/hep.31545. PMID: 32964473.
  32. Kuchibhotla A, Chakraborty S, Banerjee D (2020). Experimental validation of numerical predictions for “Deviant” density enhancement of protein emulsions in oil (Oleo‑Nanofluids). Springer Nature Applied Sciences 1617. https://doi.org/10.1007/s42452-020-03422-6.
  33. Johnson SC, Chakraborty S, Anastasios Drosou A, Paula Cunnea P, Dimitrios Tzovara D, Katherine Nixon K, Zawieja DC, Muthuchamy M, Fotopoulou C and Moore jr JE (2020). Inflammatory state of lymphatic vessels and miRNA profiles associated with relapse in ovarian cancer patients.  Plos One July 27, https://doi.org/10.1371/journal.pone.0230092. PMID: 32716937.
  34. Lee Y, Chakraborty S, Muthuchamy M (2020). Roles of sarcoplasmic reticulum Ca2+ ATPase pump in the impairments of lymphatic contractile activity in a metabolic syndrome rat model. Sci Rep. 2020. July 23;10, 12320. https://doi.org/10.1038/s41598-020-69196-4. PMID: 32704072.
  35. Roy S, Kumaravel S, Duran CL, Bayless KJ, Chakraborty S (2020). Hypoxic tumor microenvironment: Implications for cancer therapy. June 27. Experimental Biology & Medicine PMID: 32594767.
  36. Kumaravel S, Singh S, Roy S, Venkatasamy S, White T, Sinha S, Glaser S, Safe S, Chakraborty S (2020). CXCL11-CXCR3 axis mediates tumor lymphatic crosstalk and inflammation induced tumor promoting pathways in head and neck cancers. Am J Pathol. 2020 Apr;190(4):900-915. doi: 10.1016/j.ajpath.2019.12.004. Epub 2020 Feb 5. PMID: 32035061.
  37. Roy S, Glaser S and Chakraborty S (2019). Inflammation and progression of cholangiocarcinoma: Role of angiogenic and lymphangiogenic mechanisms. Front Med (Lausanne). Dec 18;6:293. doi: 10.3389/fmed.2019.00293. eCollection 2019. PMID: 31921870.
  38. Lee Y, Chakraborty S, Meininger CJ, Muthuchamy M (2018). Insulin resistance disrupts cell integrity, mitochondrial function and inflammatory signaling in lymphatic endothelium. Microcirculation. Jul 19: e12492. doi: 10.1111/micc.12492. PMID:30025187.
  39. Kim J*, Chakraborty S*, Jayaprakasha GK, Muthuchamy M, Patil BS (2017). Citrus nomilin down-regulates TNF-α-induced proliferation of aortic smooth muscle cells via apoptosis and inhibition of IκB. Eur J Pharmacol. May 24. pii:S0014-2999(17)30374-6. doi: 10.1016/j.ejphar.2017.05.043. PMID: 28551013. (*first author equal contribution).
  40. Y Lee, J.D Fluckey, S. Chakraborty*, M. Muthuchamy* (2017). Hyperglycemia and hyperinsulinemia induced insulin resistance causes alterations in cellular bioenergetics and activation of inflammatory signaling in lymphatic muscle. FASEB J. Mar 15. pii: fj.201600887R. doi: 10.1096/fj.201600887R (* corresponding author: equal contribution).
  41. Zawieja SD, Wang W, Chakraborty S, Zawieja DC, Muthuchamy M (2016). Macrophage alterations within the mesenteric lymphatic tissue are associated with impairment of lymphatic pump in metabolic syndrome Microcirculation.  Sep 2. doi: 10.1111/micc.12307.
  42. Chakraborty S, Zawieja S, Wang W, Zawieja DC and Muthuchamy M (2015). “Lipopolysaccharide modulates neutrophil recruitment and macrophage polarization on lymphatic vessels and impairs lymphatic function in rat mesentery” Am J Physiol Heart Circ Physiol.  Oct 9:ajpheart.00467.2015. doi: 10.1152/ajpheart.00467.2015. PMID: 26453331.
  43. Chakraborty S, Zawieja DC, Davis MJ and Muthuchamy M (2015). MicroRNA Signature of Inflamed Lymphatic Endothelium and Role of miR-9 in Lymphangiogenesis and Inflammation. Am J Physiol Cell Physiol.  Nov 15; 309(10):C680-92. doi: 10.1152/ajpcell.00122.2015. PMCID: PMC4652079.
  44. Chakraborty S, Davis MJ, Muthuchamy M Emerging trends in the pathophysiology of lymphatic contractile function. Semin Cell Dev Biol. 2015 Jan. pii: S1084-9521(15) 00007-5. doi: 10.1016/j.semcdb.2015.01.005.
  45. Dougherty PJ, Nepiyushchikh ZV, Chakraborty S, Wang W, Davis MJ, Zawieja DC, Muthuchamy M (2014). PKC activation increases Ca2+ sensitivity of permeabilized lymphatic muscle via myosin light chain 20 phosphorylation-dependent and -independent mechanisms. Am J Physiol Heart Circ Physiol. Mar; 306(5): H674-83. doi: 10.1152/ajpheart.00732.2013. PMID: 24414065; PMCID: PMC3949071.
  46. Chakraborty S, Guruswamy M, Zawieja DC, Muthuchamy M (2013). Lymphatic filariasis: perspectives on lymphatic remodeling and contractile dysfunction in filarial disease pathogenesis. Microcirculation.  Jul; 20(5): 349-64. doi: 10.1111/micc.12031. PMID 23237232; PMCID: PMC3613430.
  47. Nepiyushchikh ZV, Chakraborty S, Wang W, Davis MJ, Zawieja DC, Muthuchamy M (2011). Differential effects of myosin light chain kinase inhibition on contractility, force development and myosin light chain 20 phosphorylation of rat cervical and thoracic duct lymphatics. J Physiol. Nov 15;589(Pt 22):5415-29. doi: 10.1113/jphysiol.2011.281446. PMID: 21930597; PMCID: PMC324088.
  48. Chakraborty S, Nepiyushchikh Z, Davis MJ, Zawieja DC, Muthuchamy M (2011). Substance P activates both contractile and inflammatory pathways in lymphatics through the neurokinin receptors NK1R and NK3R. Microcirculation. Jan;18(1):24-35. doi: 10.1111/j.1549-8719.2010.00064.x. PMID: PMCID: PMC3058475.
  49. Wu X, Chakraborty S, Meininger GA, Davis MJ, Muthuchamy M (2011). Fibronectin increases the force production of mouse papillary muscles via 51 integrin. J Mol Cell Cardiol. Jan; 50(1):203-13. doi: 10.1016/j.yjmcc.2010.10.003. PMID: 20937283; PMCID: PMC3019265.
  50. Chakraborty S, Zawieja S, Wang W, Zawieja DC, Muthuchamy M (2010). Lymphatic system: a vital link between metabolic syndrome and inflammation. Ann N Y Acad Sci.  Oct;1207 Suppl 1: E94-102. doi: 10.1111/j.1749-6632.2010.05752.x. PMID: 20961312; PMCID: PMC2965625.
  51. Chakraborty S, Nagashri MN, Mohiyuddin SM, Gopinath KS, Kumar A (2010). Gene expression profiling of oral cancer by differential display RT-PCR. Indian J Surg Oncol,  Dec; 1(4): 284-93. doi: 10.1007/s13193-011-0054-x. PMID: 22693380; PMCID: PMC3244262.
  52. Wang W*, Nepiyushchikh Z*, Zawieja DC, Chakraborty S, Zawieja SD, Gashev AA, Davis MJ, Muthuchamy M (2009). Inhibition of myosin light chain phosphorylation decreases rat mesenteric lymphatic contractile activity. Am J Physiol Heart Circ Physiol. Aug; 297(2):H726-34. doi: 10.1152/ajpheart.00312.2009. PMID: 19525378; PMCID: PMC2724206.
  53. Chakraborty S, Mohiyuddin SM, Gopinath KS, Kumar A (2008). Involvement of the TSC genes and differential expression of other members of the mTOR signaling pathway in oral squamous cell carcinoma. BMC Cancer. 2008 Jun 6;8:163. doi: 10.1186/1471-2407-8-163. PMID: 18538015; PMCID: PMC2430211.
  54. Kumar A, Dorairaj SK, Prabhakaran VC, Prakash DR, Chakraborty S (2007). Identification of genes associated with tumorigenesis of meibomian cell carcinoma by microarray analysis. Genomics.  Nov;90(5):559-66. PMID: 17889501.
  55. Chakraborty S, Khare S, Dorairaj SK, Prabhakaran VC, Prakash DR, Kumar A (2007). Identification of genes associated with tumorigenesis of retinoblastoma by microarray analysis. Genomics. Sep; 90(3): 344-53. PMID: 1760459.

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