Cong X, Liu Y, Liu W, Liang X, Russell DH, Laganowsky A. Determining Membrane Protein-Lipid Binding Thermodynamics Using Native Mass Spectrometry. J Am Chem Soc. 2016 Apr 6;138(13):4346-9. doi: 10.1021/jacs.6b01771. Epub 2016 Mar 25. PubMed PMID: 27015007.

Allison TM, Reading E, Liko I, Baldwin AJ, Laganowsky A, Robinson CV. Quantifying the stabilizing effects of protein-ligand interactions in the gas phase. Nat Commun. 2015 Oct 6;6:8551. doi: 10.1038/ncomms9551. PubMed PMID: 26440106; PubMed Central PMCID: PMC4600733.

Reading E, Walton TA, Liko I, Marty MT, Laganowsky A, Rees DC, Robinson CV. The Effect of Detergent, Temperature, and Lipid on the Oligomeric State of MscL Constructs: Insights from Mass Spectrometry. Chem Biol. 2015 May 21;22(5):593-603. doi:10.1016/j.chembiol.2015.04.016. PubMed PMID: 26000747.

Reading E, Liko I, Allison TM, Benesch JL, Laganowsky A, Robinson CV. The role of the detergent micelle in preserving the structure of membrane proteins in the gas phase. Angew Chem Int Ed Engl. 2015 Apr 7;54(15):4577-81. doi: 10.1002/anie.201411622. Epub 2015 Feb 18. PubMed PMID: 25693501.

Lai YT, Reading E, Hura GL, Tsai KL, Laganowsky A, Asturias FJ, Tainer JA, Robinson CV, Yeates TO. Structure of a designed protein cage that self-assembles into a highly porous cube. Nat Chem. 2014 Dec;6(12):1065-71. doi: 10.1038/nchem.2107. Epub 2014 Nov 10. PubMed PMID: 25411884; PubMed Central PMCID: PMC4239666.

5.6.14_naturecoverLaganowsky A,Ф, § Reading E, Allison TM, Ulmschneider MB, Degiacomi MT, Baldwin AJ, Robinson CV. Membrane proteins bind lipids selectively to modulate their structure and function. Nature. 2014 Jun 5;510(7503):172-5. doi: 10.1038/nature13419. PubMed PMID: 24899312; PubMed Central PMCID: PMC4087533. ФEqual authorship, §Corresponding author. (Cover Article)




Hochberg GK, Ecroyd H, Liu C, Cox D, Cascio D, Sawaya MR, Collier MP, Stroud J, Carver JA, Baldwin AJ, Robinson CV, Eisenberg DS, Benesch JL, Laganowsky A. § The structured core domain of αB-crystallin can prevent amyloid fibrillation and associated toxicity. Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):E1562-70. doi: 10.1073/pnas.1322673111. Epub 2014 Apr 7. PubMed PMID: 24711386; PubMed Central PMCID: PMC4000792. §Corresponding author.

pasted image 97x121Hopper JT, Yu YT, Li D, Raymond A, Bostock M, Liko I, Mikhailov V, Laganowsky A, Benesch JL, Caffrey M, Nietlispach D, Robinson CV. Detergent-free mass spectrometry of membrane protein complexes. Nat Methods. 2013 Dec;10(12):1206-8. doi: 10.1038/nmeth.2691. Epub 2013 Oct 13. PubMed PMID: 24122040; PubMed Central PMCID: PMC3868940. (Cover Article)



Hilton GR, Hochberg GK, Laganowsky A, McGinnigle SI, Baldwin AJ, Benesch JL. C-terminal interactions mediate the quaternary dynamics of αB-crystallin. Philos Trans R Soc Lond B Biol Sci. 2013 Mar 25;368(1617):20110405. doi: 10.1098/rstb.2011.0405. Print 2013 May 5. PubMed PMID: 23530258; PubMed Central PMCID: PMC3638394.

pasted image 150x196Laganowsky A, Reading E, Hopper JT, Robinson CV. Mass spectrometry of intact membrane protein complexes. Nat Protoc. 2013 Apr;8(4):639-51. doi: 10.1038/nprot.2013.024. Epub 2013 Mar 7. PubMed PMID: 23471109; PubMed Central PMCID: PMC4058633.





Gallat FX, Laganowsky A, Wood K, Gabel F, van Eijck L, Wuttke J, Moulin M, Härtlein M, Eisenberg D, Colletier JP, Zaccai G, Weik M. Dynamical coupling of intrinsically disordered proteins and their hydration water: comparison with folded soluble and membrane proteins. Biophys J. 2012 Jul 3;103(1):129-36. doi: 10.1016/j.bpj.2012.05.027. PubMed PMID: 22828339; PubMed Central PMCID: PMC3388209.

Senturia R, Laganowsky A, Barr I, Scheidemantle BD, Guo F. Dimerization and heme binding are conserved in amphibian and starfish homologues of the microRNA processing protein DGCR8. PLoS One. 2012;7(7):e39688. doi: 10.1371/journal.pone.0039688. Epub 2012 Jul 2. PubMed PMID: 22768307; PubMed Central PMCID: PMC3388087.

Laganowsky A, Liu C, Sawaya MR, Whitelegge JP, Park J, Zhao M, Pensalfini A, Soriaga AB, Landau M, Teng PK, Cascio D, Glabe C, Eisenberg D. Atomic view of a toxic amyloid small oligomer. Science. 2012 Mar 9;335(6073):1228-31. doi: 10.1126/science.1213151. PubMed PMID: 22403391; PubMed Central PMCID: PMC3959867.

  • Covered by Science in a ‘perspective’ article “Visualizing Amyloid Assembly”, Science 2012, 336:308-309
  • Covered by Nature Structural & Molecular Biology in Research Highlights “A glimpse at toxicity ”NSMB 2012, 19:369
  • Covered by Science in ‘This week in Science’ article “A Toxic Barrel”, Science 2012, 335:1146
  • Covered at the Alzheimer Research Forum (
  • Ranked “must read” in Faculty of 1000

Colletier JP, § Laganowsky A, § Landau M, § Zhao M, Soriaga AB, Goldschmidt L, Flot D, Cascio D, Sawaya MR, Eisenberg D. Molecular basis for amyloid-beta polymorphism. Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):16938-43. doi: 10.1073/pnas.1112600108. Epub 2011 Sep 23. PubMed PMID: 21949245; PubMed Central PMCID: PMC3193189. §Equal authorship

Laganowsky A, Zhao M, Soriaga AB, Sawaya MR, Cascio D, Yeates TO. An approach to crystallizing proteins by metal-mediated synthetic symmetrization. Protein Sci. 2011 Nov;20(11):1876-90. doi: 10.1002/pro.727. Epub 2011 Sep 30. PubMed PMID: 21898649; PubMed Central PMCID: PMC3267952. Ranked “must read” in Faculty of 1000.

Landau M, Sawaya MR, Faull KF, Laganowsky A, Jiang L, Sievers SA, Liu J, Barrio JR, Eisenberg D. Towards a pharmacophore for amyloid. PLoS Biol. 2011 Jun;9(6):e1001080. doi: 10.1371/journal.pbio.1001080. Epub 2011 Jun 14. PubMed PMID: 21695112; PubMed Central PMCID: PMC3114762.

Webb KJ, Zurita-Lopez CI, Al-Hadid Q, Laganowsky A, Young BD, Lipson RS, Souda P, Faull KF, Whitelegge JP, Clarke SG. A novel 3-methylhistidine modification of yeast ribosomal protein Rpl3 is dependent upon the YIL110W methyltransferase. J Biol Chem. 2010 Nov 26;285(48):37598-606. doi: 10.1074/jbc.M110.170787. Epub 2010 Sep 23. PubMed PMID: 20864530; PubMed Central PMCID: PMC2988365.

Laganowsky A, Eisenberg D. Non-3D domain swapped crystal structure of truncated zebrafish alphaA crystallin. Protein Sci. 2010 Oct;19(10):1978-84. doi: 10.1002/pro.471. PubMed PMID: 20669149; PubMed Central PMCID: PMC2998731.

pasted image 95x124Laganowsky A, Benesch JL, Landau M, Ding L, Sawaya MR, Cascio D, Huang Q, Robinson CV, Horwitz J, Eisenberg D. Crystal structures of truncated alphaA and alphaB crystallins reveal structural mechanisms of polydispersity important for eye lens function. Protein Sci. 2010 May;19(5):1031-43. doi: 10.1002/pro.380. PubMed PMID: 20440841; PubMed Central PMCID: PMC2868245.



Puppione DL, Donna LD, Laganowsky AD, Bassilian S, Souda P, Ryder OA, Whitelegge JP. Mass spectral analyses of the two major apolipoproteins of great ape high density lipoproteins. Comp Biochem Physiol Part D Genomics Proteomics. 2009 Dec;4(4):305-9. PubMed PMID: 21298813; PubMed Central PMCID: PMC2776726.

Laganowsky A, Gómez SM, Whitelegge JP, Nishio JN. Hydroponics on a chip: analysis of the Fe deficient Arabidopsis thylakoid membrane proteome. J Proteomics. 2009 Apr 13;72(3):397-415. PubMed PMID: 19367733.

Webb KJ, Laganowsky A, Whitelegge JP, Clarke SG. Identification of two SET domain proteins required for methylation of lysine residues in yeast ribosomal protein Rpl42ab. J Biol Chem. 2008 Dec 19;283(51):35561-8. doi: 10.1074/jbc.M806006200. Epub 2008 Oct 28. PubMed PMID: 18957409; PubMed Central PMCID: PMC2602916.

Whitelegge JP, Laganowsky A, Nishio J, Souda P, Zhang H, Cramer WA. Sequencing covalent modifications of membrane proteins. J Exp Bot. 2006;57(7):1515-22. Epub 2006 Mar 30. PubMed PMID: 16574746.  

Book Chapter

Faull KF, Dooley AN, Halgand F, Shoemaker LD, Norris AJ, Ryan CM, Laganowsky A, Johnson JV, Katz JE. “An introduction to the basic principles and concepts of mass spectrometry.” In: D. Barcelo, editor: Comprehensive Analytical Chemistry, Vol 52, Protein Mass Spectrometry, Julian P. Whitelegge. Elsevier BV: Elsevier, 2009, pp. 1–46. ISBN: 9780444530554


Laganowsky A. “Structural studies of amyloid-related proteins”, (PhD dissertation, University of California, Los Angeles, 2011). Biochemistry Distinguished Dissertation Award

Thesis Laganowsky A. “Proteomic analyses of thylakoids using LCMS+ reveal changes in protein expression patterns and post transcriptional alteration in Fe deficient Arabidopsis thaliana”, (MS thesis, California State University, Chico, 2006).