Lab Members

Principle Investigator – Zhilei Chen (zchen4@tamu.edu)


Appointments
2008 – 2014, Assistant Professor, Chemical Engineering, Texas A&M University
2014 – 2016, Assistant Professor, Microbial Pathogenesis and Immunology, Texas A&M University Health Science Center
2016 – present, Associate Professor, Microbial Pathogenesis and Immunology, Texas A&M University Health Science Center

Education
2000 B.S, Physics, East China Normal University
2006 Ph.D, Biophysics, University of Illinois at Urbana-Champaign
2008 Postdoc, Virology, Rockefeller University

Honors and Awards
2002, 2003 Student Conference Travel Grant, UIUC
2004 Outstanding Student Oral Presentation in the CMB/Biophysics Symposium, UIUC
2006 Eugene Rabinowich Graduate Fellowship, UIUC
2012 National Science Foundation CAREER
2013 Texas A&M Engineering Experiment Station Select Young Faculty
2017 NIH New Innovator Award

Zhilei Chen received her B.S. in Physics from the East China Normal University and completed her PhD in Biophysics at the University of Illinois, Urbana-Champaign working with Huimin Zhao on the directed evolution of proteins as gene switches and precision DNA scissors for gene therapy. These works fostered her passion for biotherapeutics engineering and inspired her to join the laboratory of Charles Rice at the Rockefeller University for her postdoctoral studies where she developed high-throughput assays to identify small molecule antivirals against hepatitis C virus, an underrecognized public health threat with a worldwide occurrence rate that is nearly five times that for HIV. Research in the Chen Medicinal Protein Lab integrates tools from protein engineering, e.g. phage display, yeast display, high-throughput screening, with those applied in virology, bacteriology and immunology with the goal of developing a new generation of protein-based therapeutics. Her current research program centers on the engineering of antibody surrogate proteins, especially those that are compatible with high yield production by microbial recombinant expression hosts, for the treatment and/or prevention of viral (Zika, influenza, hepatitis) and bacterial (Clostridium difficile and pathogenic E. coli) infections. In addition to contemplating both the identity and the potential Achilles’ heel of the next infectious agent, Zhilei enjoys reading, cooking, doing Yoga and working out with her trainer.


Research Assistant Professor – Pete Heinzelman (2017 – )

1999 B.S. Chemical Engineering, University of Wisconsin-Madison
2002 M.S. Chemical Engineering, Massachusetts Institute of Technology
2006 Ph.D. Chemical Engineering, Massachusetts Institute of Technology
2010 Post-doc. Chemical engineering, California Institute of Technology
Email: proteinpete AT gmail.com

One in three Americans over the age of 85 are afflicted with Alzheimer’s Disease (AD). With population demographics shifting toward higher representation of elderly persons not only in the United States but also around the world developing new technologies to manage, prevent and possibly even reverse this debilitating condition stands behind only mitigation of global warming as the most pressing scientific challenge of our time. As a member of the Chen Medicinal Protein Lab (CMPL) Dr. Heinzelman applies a diverse collection of protein engineering and molecular biology tools, which has been acquired and refined during his research experiences at world class institutions including MIT, Caltech and Mayo Clinic, to expand the scope of the CMPL’s translational research portfolio by contributing to initiatives aimed at developing new platforms for diagnosis, treatment and prophylaxis of both infectious diseases and neurodegenerative conditions such as AD and Multiple Sclerosis (MS).

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The CytoBits high-throughput biomarker discovery platform, a yeast surface-display based approach for identifying protein structural features that distinguish particular cell types or disease states, is at the heart of Dr. Heinzelman’s efforts to advance the CMPL’s pursuits in the areas both AD and MS. This technology platform, along with utilization of more traditional yeast surface display protein engineering methodologies, is also a key element of Dr. Heinzelman’s involvement in CMPL projects focused on developing biologic drugs for treating and preventing influenza, Zika virus and other communicable health conditions.

The AD-focused translational research being performed by Dr. Heinzelman and other CMPL team members leverages both CytoBits biomarker discovery methods and fluorescence activated cell sorting (FACS)-assisted yeast surface display engineering of biologic drug properties with the goal of developing clinically relevant biomedical technologies that can be synergistically integrated to reduce the ever-growing economic and quality of life burdens that AD exerts upon millions of persons across all corners of the world. In particular, the CMPL is pursuing an AD research program that brings innovative new approaches to overcoming long-standing obstacles in three technological development focus areas: targeted drug delivery to the central nervous system, diagnostic assays that provide ‘Windows Into The Brain’ by allowing both prediction of AD onset and monitoring of AD therapeutic efficacy through analysis of noninvasively collected blood samples, and ‘catalytically advantaged’ biologic drugs that can rebalance the aberrant brain protein biochemistry associated with AD by efficiently reducing levels of pathogenic AD proteins even when these drugs are present in the brain parenchyma at very low concentrations. Various elements of the armamentarium of biomolecular engineering capabilities being applied by Dr. Heinzelman and other CMPL scientists in the context of these three AD-centric research thrusts are also being turned toward the establishment of both new blood sample-based Multiple Sclerosis diagnostic platforms and next generation modalities for treating this chronic and incapacitating neurodegenerative condition.

As is the case for his colleagues in the CMPL, Dr. Heinzelman maintains a daily and unwavering focus on pushing the group closer to its goal of having a wide-ranging clinical impact in the arenas of transmissible viral disease, bacterial infections and central nervous system disorders such as AD and MS. Dr. Heinzelman augments the exhilaration and sense of purpose derived from this research regimen through blending in saw-sharpening activities that include weightlifting, running, cooking, sending emails with alliterative subject lines, and waiting for the Dallas Cowboys to win another Super Bowl.

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Postdoc – Rudo Simeon (2016 – )

2007 B.S. Chemical Engineering, Howard University
2013 Ph.D. Chemical Engineering, Texas A&M University
Email: tgrudo AT gmail.com

 

 



Postdoc – Zeyu Peng (2017 – )

2008 B.S. Biochemistry, Ocean University of China
2014 Ph.D. Biochemistry, Kansas State University
2017 Post-doc. Chemistry, University of California Davis
Email: zpeng AT tamu.edu

 

 


PhD student – Gunhye Lee (2012 – )
Chemical Engineering
BS. Chemical Engineering, Chiba University, Japan, 2012
E-mail: lhae23 AT tamu.edu

 

 

 


Undergraduate researcher – Elaine Chen (2016 – )

 

 

 


 Lab Alumni

Former Postdocs

  1. Lillian Yi Li, 2009-2010
  2. Atul Kumar, 2010
  3. Karuppiah Chockalingam, 2008-2011 (Currently senior scientist, FujiFilm Biosynth)
  4. Dagmara Korona, 2012-2013
  5. Dongli Guan, 2012-2014 (Currently scientist at Brammer Bio)
  6. Ana Chamoun, 2014-2016 (Currently postdoc fellow, Texas A&M University Veterinary Medicine)

Former Graduate Student

  1. Rudo Simeon, 2009-2013, Ph.D. East Bay Municipal Utility District, California
  2. Cory Klemashevich, 2009-2012, MS
  3. Miguel Ramirez, 2008-2013, Ph.D. University of Otago, New Zealand
  4. Ana Chamoun, 2009-2014, Ph.D. (Currently postdoc fellow, Texas A&M University Veterinary Medicine)
  5. Lizy Yu, 2016-2017
  6. Nagarjun Kasaraneni, 2012-2017, Ph.D. (Current scientist at Lonza-Viral Therapy)

Former Visiting Scholar

  1. Xuesong Liang, 2012-2013. M.D. Department of Infectious Disease, Shanghai Changhai Hospital.

Former Undergraduate Students

  1. Taylor Sugg, 2009
  2. Juan Sebastian Jerez, 2010
  3. Najla Valdes, 2008-2012
  4. Osama Qureshi, 2010
  5. Jeanene Tomecek, 2012
  6. Ivan Barrera, 2012
  7. Vivian Salamanca, 2011
  8. Daniel Jacobsen, 2010
  9. Thomas McMillian, 2012-2013
  10. Partho Giri, 2012
  11. John Roger, 2012-2013
  12. Corbin Williams, 2013