Jon T. Skare, Ph.D.
Professor and Associate Chair
B.S. University of California at Irvine (1986)
Ph.D. Washington State University (1992)
Postdoc. University of California-Los Angeles (1992-96)
My laboratory studies Borrelia burgdorferi, the spirochetal bacterium that causes Lyme disease. B. burgdorferi is the most common arthropod-borne infectious agent in the United States, with over 35,000 cases reported to the CDC in 2008. This number represented a 30% increase from the previous year, indicating that B. burgdorferi is a re-emerging infectious agent.
The goals of my research are to understand how B. burgdorferi causes disease and adapts to different niches it occupies by: (1) addressing the role of attachment, colonization and subsequent dissemination using newly developed genetic methodologies to inactivate genes involved in adherence ofB. burgdorferi to host tissues; and (2) understanding how B. burgdorferiresponds to oxidative stress via the function of the global regulatory protein BosR.