Kristin Patrick, Ph.D.
B.A. Hamilton College (2003)
Ph.D. Yale University (2008)
Postdoc University of California, San Francisco (2009-2014)
Myriad gene expression changes occur when a macrophage is infected with a pathogen such as Mycobacterium tuberculosis (Mtb). Notably, the macrophage upregulates various innate immune molecules to activate cellular defense mechanisms and promote destruction of the bacterium. At the same time, Mtb induces another set of gene expression changes in order to subvert the innate immune response and set up a replicative niche inside the macrophage. My interests lie in understanding the precise spatial-temporal resolution of RNA processing events in Mtb infected macrophages during early infection